ACTION Biomarker Study v1

Abstract

The goal of ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strategies) was to identify precursors, features, and consequences of childhood aggression using epidemiological and omics-driven studies. A considerable effort within ACTION was the collection of new omics data in children with low and high aggressive behavior. To this end, the ACTION project included large-scale collection of biological samples in children from the Netherlands Twin Register (NTR), a twin cohort from the general population, and a cohort of children referred for psychiatric treatment (LUMC-Curium). Together these cohorts comprise the ACTION Biomarker Study. This documentation describes the study design and data collection for the ACTION Biomarker Study.

Authors 1

1. Fiona A. Hagenbeek corresponding Aachen LUMC Curium Department of Child and Adolescent Psychiatry

   Vrije Universiteit Amsterdam · Amsterdam Public Health · Leiden University Medical Center · Amsterdam Reproduction Development · Avera Institute for Human Genetics

   Affiliation as printed

   Consortium

   Department of Biological Psychology , Vrije Universiteit Amsterdam , Amsterdam , the Netherlands ;

   Amsterdam Public Health Research Institute, Amsterdam, the Netherlands;

   Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands;

   Avera Institute for Human Genetics, Sioux Falls, South Dakota, United States of America;

   Consortium Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands;

   Institute, the Hague, the Netherlands ;

   LUMC-Curium, Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Oegstgeest, the Netherlands;