COVID-19 does not influence functional status after ARDS therapy

Critical Care, vol. 27, pp. 48

Abstract

RATIONALE: Health-related quality of life after surviving acute respiratory distress syndrome has come into focus in recent years, especially during the coronavirus disease 2019 pandemic. OBJECTIVES: A total of 144 patients with acute respiratory distress syndrome caused by COVID-19 or of other origin were recruited in a randomized multicenter trial. METHODS: Clinical data during intensive care treatment and data up to 180 days after study inclusion were collected. Changes in the Sequential Organ Failure Assessment score were used to quantify disease severity. Disability was assessed using the Barthel index on days 1, 28, 90, and 180. MEASUREMENTS: Mortality rate and morbidity after 180 days were compared between patients with and without COVID-19. Independent risk factors associated with high disability were identified using a binary logistic regression. MAIN RESULTS: The SOFA score at day 5 was an independent risk factor for high disability in both groups, and score dynamic within the first 5 days significantly impacted disability in the non-COVID group. Mortality after 180 days and impairment measured by the Barthel index did not differ between patients with and without COVID-19. CONCLUSIONS: Resolution of organ dysfunction within the first 5 days significantly impacts long-term morbidity. Acute respiratory distress syndrome caused by COVID-19 was not associated with increased mortality or morbidity.

Authors 10

1. Alice Marie Bernard

   Universitätsklinikum Tübingen · University of Tübingen

   Affiliation as printed

   Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Universitätsklinikum Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany

2. Lina María Serna-­Higuita

   University of Tübingen

   Affiliation as printed

   Institute for Clinical Epidemiology and Applied Biometry, Faculty of Medicine, University of Tübingen, Tübingen, Germany

3. Peter Martus

   University of Tübingen

   Affiliation as printed

   Institute for Clinical Epidemiology and Applied Biometry, Faculty of Medicine, University of Tübingen, Tübingen, Germany

4. Valbona Mirakaj

   Universitätsklinikum Tübingen · University of Tübingen

   Affiliation as printed

   Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Universitätsklinikum Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany

5. Michael Koeppen

   Universitätsklinikum Tübingen · University of Tübingen

   Affiliation as printed

   Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Universitätsklinikum Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany

6. Alexander Zarbock

   University of Münster

   Affiliation as printed

   Department of Anesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany

7. Gernot Marx Aachen Department of Intensive Care Medicine

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Intensive Care Medicine, University Hospital RWTH Aachen, Aachen, Germany

8. Christian Putensen

   University of Bonn · University Hospital Bonn

   Affiliation as printed

   Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany

9. Peter Rosenberger corresponding

   Universitätsklinikum Tübingen · University of Tübingen

   Affiliation as printed

   Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Universitätsklinikum Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany. peter.rosenberger@medizin.uni-tuebingen.de

   Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Universitätsklinikum Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany

10. Helene Anna Haeberle corresponding

    Universitätsklinikum Tübingen · University of Tübingen

    Affiliation as printed

    Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Universitätsklinikum Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany. helene.haeberle@medizin.uni-tuebingen.de

    Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Universitätsklinikum Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany