Micro RNA in meniscal ailments: current concepts

British Medical Bulletin, vol. 145, pp. 141–150

Abstract

INTRODUCTION: Micro RNAs (miRNAs) are short non-coding RNAs that act primarily in posttranscriptional gene silencing, and are attracting increasing interest in musculoskeletal conditions. SOURCE OF DATA: Current scientific literature published in PubMed, Google Scholar, Embase and Web of Science databases. AREAS OF AGREEMENT: Recently, the potential of miRNAs as biomarkers for diagnosis and treatment of meniscal injuries has been postulated. AREAS OF CONTROVERSY: Evaluation of the role of miRNAs in patients with meniscal tears is still controversial. GROWING POINTS: A systematic review was conducted to investigate the potential of miRNA in the diagnosis and management of meniscal damage. AREAS TIMELY FOR DEVELOPING RESEARCH: Intra-articular injection of microRNA-210 in vivo may represent a potential innovative methodology for the management of meniscal injuries. Characterization of the miRNAs expression in the synovial fluid could lead to the development of better early diagnosis and management strategies for meniscal tears.

Authors 6

1. Filippo Migliorini Aachen Department of Orthopaedic and Trauma Surgery

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Orthopaedic and Trauma Surgery, RWTH University Hospital Aachen , Pauwelsstraße 30, 52074 Aachen , Germany

2. Gianluca Vecchio

   University of Salerno

   Affiliation as printed

   Department of Medicine , Surgery and Dentistry, , Baronissi 84081 , Italy

   University of Salerno , Surgery and Dentistry, , Baronissi 84081 , Italy

   Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi 84081, Italy

3. Riccardo Giorgino

   IRCCS Ospedale Galeazzi - Sant'Ambrogio

   Affiliation as printed

   Department of Orthopedics, IRCCS Orthopaedic Institute Galeazzi , Milano 20161 , Italy

4. Jörg Eschweiler Aachen Department of Orthopaedic and Trauma Surgery

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Orthopaedic and Trauma Surgery, RWTH University Hospital Aachen , Pauwelsstraße 30, 52074 Aachen , Germany

5. Frank Hildebrand Aachen Department of Orthopaedic and Trauma Surgery

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Orthopaedic and Trauma Surgery, RWTH University Hospital Aachen , Pauwelsstraße 30, 52074 Aachen , Germany

6. Nicola Maffulli corresponding

   Queen Mary University of London · Mile End Hospital · IRCCS Ospedale Galeazzi - Sant'Ambrogio · Keele University

   Affiliation as printed

   Barts and the London School of Medicine and Dentistry, Centre for Sports and Exercise Medicine, Mile End Hospital, Queen Mary University of London , 275 Bancroft Road, London E1 4DG , UK

   Department of Orthopedics, IRCCS Orthopaedic Institute Galeazzi , Milano 20161 , Italy

   School of Pharmacy and Bioengineering, Keele University Faculty of Medicine , Thornburrow Drive, Stoke on Trent ST4 7QB , UK