Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels

Chemical Communications, vol. 59, pp. 2090–2093

Abstract

Benzene-1,3,5-tricarboxamide (BTA) glyco-monomers containing one, two or three mannose units are synthesized and formulated into differently patterned supramolecular glycopolymers through homo-assembly or co-assembly with non-functionalized BTAs. Unfortunately, no cellular activity could be detected. Excitingly, these glyco-BTA monomers could be formulated into hydrogels, paving the way for (immune) cell culture.

Authors 7

1. Laura Rijns

   Eindhoven University of Technology

   Affiliation as printed

   Department of Biomedical Engineering, Laboratory for Cell and Tissue Engineering, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands

   Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands

   Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands

2. Lu Su corresponding Aachen Leiden Academic Centre for Drug Research

   Leiden University

   Affiliation as printed

   Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands

3. Konrad Maxeiner

   Max Planck Institute for Polymer Research

   Affiliation as printed

   Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany

4. Giulia Morgese

   ZHAW Zurich University of Applied Sciences

   Affiliation as printed

   ZHAW Zurich University of Applied Sciences, School of Engineering, Forschungsbereich Polymere Beschichtungen, Technikumstrasse 9, Winterthur 8400, Switzerland

5. David Y. W. Ng

   Max Planck Institute for Polymer Research

   Affiliation as printed

   Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany

6. Tanja Weil

   Max Planck Institute for Polymer Research

   Affiliation as printed

   Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany

7. Patricia Y. W. Dankers corresponding

   Eindhoven University of Technology

   Affiliation as printed

   Department of Biomedical Engineering, Laboratory for Cell and Tissue Engineering, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands

   Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands

   Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands