Individual Differences in Delay Discounting are Associated with Dorsal Prefrontal Cortex Connectivity in Youth

bioRxiv (Cold Spring Harbor Laboratory)

Abstract

Delay discounting is a measure of impulsive choice relevant in adolescence as it predicts many real-life outcomes, including substance use disorders, obesity, and academic achievement. However, the functional networks underlying individual differences in delay discounting during youth remain incompletely described. Here we investigate the association between multivariate patterns of functional connectivity and individual differences in impulsive choice in a large sample of youth. A total of 293 youth (9-23 years) completed a delay discounting task and underwent resting-state fMRI at 3T. A connectome-wide analysis using multivariate distance-based matrix regression was used to examine whole-brain relationships between delay discounting and functional connectivity was then performed. These analyses revealed that individual differences in delay discounting were associated with patterns of connectivity emanating from the left dorsal prefrontal cortex, a hub of the default mode network. Delay discounting was associated with greater functional connectivity between the dorsal prefrontal cortex and other parts of the default mode network, and reduced connectivity with regions in the dorsal and ventral attention networks. These results suggest that delay discounting in youth is associated with individual differences in relationships both within the default mode network and between the default mode and networks involved in attentional and cognitive control.

Authors 16

1. Kahini P. Mehta

   University of Pennsylvania

   Affiliation as printed

   Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 904, USA

2. Adam Robert Pines

   University of Pennsylvania

   Affiliation as printed

   Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 904, USA

3. Azeez Adebimpe

   University of Pennsylvania

   Affiliation as printed

   Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 904, USA

4. Bart L. Larsen

   University of Pennsylvania

   Affiliation as printed

   Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 904, USA

5. Dani S. Bassett

   Santa Fe Institute · University of Pennsylvania

   Affiliation as printed

   Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, PA 19104, USA

   Department of Electrical & Systems Engineering, University of Pennsylvania, PA 19104, USA

   Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Department of Physics & Astronomy, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Santa Fe Institute, Santa Fe, NM, 87051, USA

   Department of Electrical & Systems Engineering, University of Pennsylvania, PA 1910, USA

   Department of Physics & Astronomy, University of Pennsylvania, Philadelphia, PA, 1104, USA

6. Monica E. Calkins

   University of Pennsylvania

   Affiliation as printed

   Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

7. Erica B. Baller

   University of Pennsylvania

   Affiliation as printed

   Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 904, USA

8. Martin Gell Aachen Department of Psychiatry, Psychotherapy and Psychosomatics Medical Faculty

   Forschungszentrum Jülich · University of Pennsylvania · RWTH Aachen University

   Affiliation as printed

   Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany

   Institute of Neuroscience and Medicine (INM-7: Brain & Behaviour), Research Centre Jülich, Jülich, Germany

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

   Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 904, USA

9. Lauren M. Patrick

   University of Pennsylvania

   Affiliation as printed

   Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA

10. Raquel E. Gur

    Children's Hospital of Philadelphia · University of Pennsylvania

    Affiliation as printed

    Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA

11. Ruben C. Gur

    Children's Hospital of Philadelphia · University of Pennsylvania

    Affiliation as printed

    Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA

12. David R. Roalf

    University of Pennsylvania

    Affiliation as printed

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

13. Daniel Römer

    University of Pennsylvania

    Affiliation as printed

    Annenberg Public Policy Center, University of Pennsylvania, Philadelphia, PA 19104, USA

14. Daniel H. Wolf

    University of Pennsylvania

    Affiliation as printed

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

15. Joseph W. Kable

    University of Pennsylvania

    Affiliation as printed

    Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA

16. Theodore Daniel Satterthwaite corresponding

    Children's Hospital of Philadelphia · University of Pennsylvania

    Affiliation as printed

    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

    Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA

    Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 904, USA