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January 25, 2023 article Open access Aachen paper

Deep learning based identification of bone scintigraphies containing metastatic bone disease foci

Cancer Imaging, vol. 23, pp. 12

DOI: 10.1186/s40644-023-00524-3 Full text (OA) OpenAlex

Abstract

PURPOSE: Metastatic bone disease (MBD) is the most common form of metastases, most frequently deriving from prostate cancer. MBD is screened with bone scintigraphy (BS), which have high sensitivity but low specificity for the diagnosis of MBD, often requiring further investigations. Deep learning (DL) - a machine learning technique designed to mimic human neuronal interactions- has shown promise in the field of medical imaging analysis for different purposes, including segmentation and classification of lesions. In this study, we aim to develop a DL algorithm that can classify areas of increased uptake on bone scintigraphy scans. METHODS: We collected 2365 BS from three European medical centres. The model was trained and validated on 1203 and 164 BS scans respectively. Furthermore we evaluated its performance on an external testing set composed of 998 BS scans. We further aimed to enhance the explainability of our developed algorithm, using activation maps. We compared the performance of our algorithm to that of 6 nuclear medicine physicians. RESULTS: The developed DL based algorithm is able to detect MBD on BSs, with high specificity and sensitivity (0.80 and 0.82 respectively on the external test set), in a shorter time compared to the nuclear medicine physicians (2.5 min for AI and 30 min for nuclear medicine physicians to classify 134 BSs). Further prospective validation is required before the algorithm can be used in the clinic.

Authors 18

  1. Abdalla Ibrahim Aachen Department of Nuclear Medicine and Comprehensive diagnostic center Aachen (CDCA)

    University of Liège · Columbia University Irving Medical Center · Maastricht University · Universitätsklinikum Aachen · Centre Hospitalier Universitaire de Liège · Columbia University · RWTH Aachen University

    Affiliation as printed

    Department of Nuclear Medicine and Comprehensive diagnostic centre Aachen (CDCA), University Hospital RWTH Aachen University, Aachen, Germany

    Department of Radiology and Nuclear Medicine, Columbia University Irving Medical Center, New York, United States

    Division of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, University Hospital of Liege, Liege, Belgium

    The D-Lab, Department of Precision Medicine, GROW- School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

  2. Akshayaa Vaidyanathan

    Maastricht University

    Affiliation as printed

    Radiomics (Oncoradiomics SA), Liege, Belgium. akshayaa.vaidyanathan@radiomics.bio

    The D-Lab, Department of Precision Medicine, GROW- School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands. akshayaa.vaidyanathan@radiomics.bio

    The D-Lab, Department of Precision Medicine, GROW- School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

  3. Sergey P. Primakov

    Columbia University Irving Medical Center · Maastricht University · Columbia University

    Affiliation as printed

    Department of Radiology and Nuclear Medicine, Columbia University Irving Medical Center, New York, United States

    The D-Lab, Department of Precision Medicine, GROW- School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

  4. Flore Belmans

    OncoMark (Ireland) · Onco Lille

    Affiliation as printed

    Radiomics (Oncoradiomics SA), Liege, Belgium

  5. Turkey Refaee

    Maastricht University · Jazan University

    Affiliation as printed

    Department of Diagnostic Radiology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia

    The D-Lab, Department of Precision Medicine, GROW- School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

  6. Pierre Lovinfosse

    University of Liège · Centre Hospitalier Universitaire de Liège

    Affiliation as printed

    Division of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, University Hospital of Liege, Liege, Belgium

  7. Alexandre Jadoul

    University of Liège · Centre Hospitalier Universitaire de Liège

    Affiliation as printed

    Division of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, University Hospital of Liege, Liege, Belgium

  8. Céline Derwael

    University of Liège · Centre Hospitalier Universitaire de Liège

    Affiliation as printed

    Division of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, University Hospital of Liege, Liege, Belgium

  9. Fabian Hertel Aachen Department of Nuclear Medicine and Comprehensive diagnostic center Aachen (CDCA)

    Universitätsklinikum Aachen · RWTH Aachen University

    Affiliation as printed

    Department of Nuclear Medicine and Comprehensive diagnostic centre Aachen (CDCA), University Hospital RWTH Aachen University, Aachen, Germany

  10. Henry C. Woodruff

    Columbia University Irving Medical Center · Maastricht University · Columbia University

    Affiliation as printed

    Department of Radiology and Nuclear Medicine, Columbia University Irving Medical Center, New York, United States

    The D-Lab, Department of Precision Medicine, GROW- School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

  11. Helle Damgaard Zacho

    Aalborg University Hospital · Aalborg University

    Affiliation as printed

    Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

    Department of Nuclear Medicine, Clinical Cancer Research Centre, Aalborg University Hospital, Aalborg, Denmark

  12. Seán Walsh

    OncoMark (Ireland) · Onco Lille

    Affiliation as printed

    Radiomics (Oncoradiomics SA), Liege, Belgium

  13. Wim G. Vos

    OncoMark (Ireland) · Onco Lille

    Affiliation as printed

    Radiomics (Oncoradiomics SA), Liege, Belgium

  14. Mariaelena Occhipinti

    OncoMark (Ireland) · Onco Lille

    Affiliation as printed

    Radiomics (Oncoradiomics SA), Liege, Belgium

  15. François‐Xavier Hanin

    UCLouvain

    Affiliation as printed

    Department of Nuclear Medicine, Universite´CatholiqueUniversite´Catholique de Louvain, CHU-UCL-Namur, Ottignies-Louvain-la-Neuve, Belgium

  16. Philippe Lambin

    Columbia University Irving Medical Center · Maastricht University · Columbia University

    Affiliation as printed

    Department of Radiology and Nuclear Medicine, Columbia University Irving Medical Center, New York, United States

    The D-Lab, Department of Precision Medicine, GROW- School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

  17. Felix Manuel Mottaghy Aachen Department of Nuclear Medicine and Comprehensive diagnostic center Aachen (CDCA)

    Columbia University Irving Medical Center · Universitätsklinikum Aachen · Columbia University · RWTH Aachen University

    Affiliation as printed

    Department of Nuclear Medicine and Comprehensive diagnostic centre Aachen (CDCA), University Hospital RWTH Aachen University, Aachen, Germany

    Department of Radiology and Nuclear Medicine, Columbia University Irving Medical Center, New York, United States

  18. Roland Hustinx

    University of Liège · Centre Hospitalier Universitaire de Liège

    Affiliation as printed

    Division of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, University Hospital of Liege, Liege, Belgium

Cited by 21 stored of 23

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References 30