Minuteman – A versatile cloud computational platform for collaborative research

bioRxiv (Cold Spring Harbor Laboratory)

Abstract

Abstract Secure platforms for bio-computation are critical to foster increasingly complex and data-intensive collaborations involving biomedical data. Here, we present Minuteman – an open-source cloud computing platform that can be securely used across organizations. Minuteman can be used for hosting data sources and running computational pipelines in an organized way. The platform consists of three fundamental features, 1) data operations including collaborative data processing and analytics, 2) customizable user access management for secure dissemination of the data, and 3) interactive exploration of the data through 3 rd party (e.g. shiny, dashboard etc.) applications that can be scaled using docker containers. Strict data access rules and user-specific roles are applied across the whole platform to maintain data security. Minuteman is ideal for scenarios where data security, and privileged access are critical, such as industry-academia collaborations, and multi-institution consortiums. Using single-cell transcriptomics preprocessing, analyses and visualization pipelines across labs, we showcase the utility of the Minuteman platform for biomedical data analyses. Minuteman code is available at ( https://github.com/hayatlab/minuteman )

Authors 6

1. Xin Kai Li

   Bayer (United States)

   Affiliation as printed

   Data Integration and Historians Services, Enterprise Platforms and Infrastructure, Bayer US LLC., Pittsburgh, PA

2. Joydeep Charkaborty

   Bayer (United States)

   Affiliation as printed

   Product Platform Research, Enterprise Platforms and Infrastructure, Bayer US LLC., Morristown, NJ

3. Hayden Moore

   Bayer (United States)

   Affiliation as printed

   Infrastructure Engineering Services, Enterprise Platforms and Infrastructure, Bayer US LLC., Morristown, NJ

4. Alexis Laux‐Biehlmann
   Affiliation as printed

   Pulmonary Drug Discovery Laboratory, Bayer US LLC. Pharmaceuticals, Research & Development, Boston, MA

5. Sikander Hayat corresponding Aachen Institute of Experimental Medicine and Systems Biology

   RWTH Aachen University · Universitätsklinikum Aachen

   Affiliation as printed

   Institute of Experimental Medicine and Systems Biology, Uniklinik RWTH Aachen, Germany

   Precision Cardiology Laboratory, Bayer US LLC. Pharmaceuticals, Research & Development, Boston, MA

6. Dhawal S. Jain corresponding
   Affiliation as printed

   Pulmonary Drug Discovery Laboratory, Bayer US LLC. Pharmaceuticals, Research & Development, Boston, MA