Morphometry variations of orbitofrontal regions for increased BMI and appetite in major depression

Abstract

However, it is unclear if conceptually related atypical symptoms of changes in appetite are associated with similar neural alterations and if BMI and increasedappetite are also associated with white matter alterations. We employed a multi model structural neuroimaging approach to investigate the relationship between orbitofrontal gray and white matter with recent changes in appetite and BMI in a sample of N = 715 major depressive disorder patients. We found that increased BMI was associated with significantly lower cortical thickness and lower gray matter density in the right OFC, and in particular its medial aspect. For change in appetite, in contrast, we did not find any significant association with OFC morphometry, nor with OFC white matter connections. Bayesian model comparisons further suggested that BMI alone, but not change in appetite or a combination of both explained variance in cortical thickness of the right OFC. We further found strong to decisive evidence for the absence of an effect of BMI and appetite for most other analyses, including surface area and DTI measures of all OFC regions. Taken together, our findings thus suggest that BMI related alterations in OFC morphometry cannot be traced back to changes in appetite in major depression, indicating a region and modality specific effect for BMI.

Authors 31

1. David M. A. Mehler Aachen Department of Psychiatry, Psychotherapy and Psychosomatics Faculty of Medicine

   University of Münster · RWTH Aachen University

   Affiliation as printed

   Department of Psychiatry, Psychotherapy and Psychosomatics , Faculty of Medicine , RWTH Aachen , Germany

   Institute for Translational Psychiatry , University of Münster , Germany

   Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen, Germany

   Institute for Translational Psychiatry, University of Münster, Germany

2. Nils Opel

   University of Münster · Friedrich Schiller University Jena

   Affiliation as printed

   Department of Psychiatry, University of Jena, Germany

   Institute for Translational Psychiatry, University of Münster, Germany

   Interdisciplinary Center of Clinical Research (IZKF), University of Münster, Germany

3. Jonathan Repple

   University of Münster

   Affiliation as printed

   Institute for Translational Psychiatry , University of Münster , Germany

   Institute for Translational Psychiatry, University of Münster, Germany

4. Nils B. Kroemer

   University of Tübingen

   Affiliation as printed

   Department of Psychiatry , University of Tübingen , Germany

   Department of Psychiatry, University of Tübingen, Germany

5. Maike Frederike Richter

   University of Münster

   Affiliation as printed

   Institute for Translational Psychiatry , University of Münster , Germany

   Institute for Translational Psychiatry, University of Münster, Germany

6. Janik Goltermann

   University of Münster

   Affiliation as printed

   Institute for Translational Psychiatry , University of Münster , Germany

   Institute for Translational Psychiatry, University of Münster, Germany

7. Susanne L. Meinert

   University of Münster

   Affiliation as printed

   Institute for Translational Psychiatry , University of Münster , Germany

   Institute for Translational Psychiatry, University of Münster, Germany

8. Lena Waltemate

   University of Münster

   Affiliation as printed

   Institute for Translational Psychiatry , University of Münster , Germany

   Institute for Translational Psychiatry, University of Münster, Germany

9. Verena Enneking

   University of Münster

   Affiliation as printed

   Institute for Translational Psychiatry , University of Münster , Germany

   Institute for Translational Psychiatry, University of Münster, Germany

10. Melissa Klug

    University of Münster

    Affiliation as printed

    Institute for Translational Psychiatry , University of Münster , Germany

    Institute for Translational Psychiatry, University of Münster, Germany

11. Tiana Borgers

    University of Münster

    Affiliation as printed

    Institute for Translational Psychiatry , University of Münster , Germany

    Institute for Translational Psychiatry, University of Münster, Germany

12. Katharina Thiel

    University of Münster

    Affiliation as printed

    Institute for Translational Psychiatry , University of Münster , Germany

    Institute for Translational Psychiatry, University of Münster, Germany

13. Alexandra Winter

    University of Münster

    Affiliation as printed

    Institute for Translational Psychiatry , University of Münster , Germany

    Institute for Translational Psychiatry, University of Münster, Germany

14. Marius Gruber

    University of Münster

    Affiliation as printed

    Institute for Translational Psychiatry , University of Münster , Germany

    Institute for Translational Psychiatry, University of Münster, Germany

15. Marco Mauritz

    University of Münster

    Affiliation as printed

    Institute for Translational Psychiatry , University of Münster , Germany

    Institute for Translational Psychiatry, University of Münster, Germany

16. Hannah Lemke

    University of Münster

    Affiliation as printed

    Institute for Translational Psychiatry , University of Münster , Germany

    Institute for Translational Psychiatry, University of Münster, Germany

17. Dominik Grotegerd

    University of Münster

    Affiliation as printed

    Institute for Translational Psychiatry , University of Münster , Germany

    Institute for Translational Psychiatry, University of Münster, Germany

18. Steffen Edgren

    University of Münster

    Affiliation as printed

    Institute for Translational Psychiatry , University of Münster , Germany

    Institute for Translational Psychiatry, University of Münster, Germany

19. Katharina Brosch

    Philipps University of Marburg

    Affiliation as printed

    Department of Psychiatry , University of Marburg , Germany

    Department of Psychiatry, University of Marburg, Germany

20. Tina Meller

    Philipps University of Marburg

    Affiliation as printed

    Department of Psychiatry , University of Marburg , Germany

    Department of Psychiatry, University of Marburg, Germany

21. Kai G. Ringwald

    Philipps University of Marburg

    Affiliation as printed

    Department of Psychiatry, University of Marburg, Germany

22. Julia‐Katharina Pfarr

    Philipps University of Marburg

    Affiliation as printed

    Department of Psychiatry, University of Marburg, Germany

23. Simon Schmitt

    Philipps University of Marburg

    Affiliation as printed

    Department of Psychiatry , University of Marburg , Germany

    Department of Psychiatry, University of Marburg, Germany

24. Frederike Stein

    Philipps University of Marburg

    Affiliation as printed

    Department of Psychiatry , University of Marburg , Germany

    Department of Psychiatry, University of Marburg, Germany

25. Andreas Jansen

    Philipps University of Marburg

    Affiliation as printed

    Department of Psychiatry , University of Marburg , Germany

    Department of Psychiatry, University of Marburg, Germany

26. Axel Krug

    Philipps University of Marburg

    Affiliation as printed

    Department of Psychiatry , University of Marburg , Germany

    Department of Psychiatry, University of Marburg, Germany

27. Igor Nenadić

    Philipps University of Marburg

    Affiliation as printed

    Department of Psychiatry , University of Marburg , Germany

    Department of Psychiatry, University of Marburg, Germany

28. Tim Hahn

    University of Münster

    Affiliation as printed

    Institute for Translational Psychiatry , University of Münster , Germany

    Institute for Translational Psychiatry, University of Münster, Germany

29. Martin Walter

    Friedrich Schiller University Jena

    Affiliation as printed

    Department of Psychiatry , University of Jena , Germany

    Department of Psychiatry, University of Jena, Germany

30. Tilo T. J. Kircher

    Philipps University of Marburg · University of Münster

    Affiliation as printed

    Department of Psychiatry , University of Münster , Albert-Schweitzer-Str. 11 , 48149 Münster , Germany,

    Department of Psychiatry, University of Marburg, Germany

31. Udo Dannlowski

    University of Münster

    Affiliation as printed

    Institute for Translational Psychiatry , University of Münster , Germany

    N. Opel , Department of Psychiatry , University of Münster , Albert-Schweitzer-Str. 11 , 48149 Münster , Germany,

    Institute for Translational Psychiatry, University of Münster, Germany