Multiomic Spatial Mapping of Myocardial Infarction and Implications for Personalized Therapy

Arteriosclerosis Thrombosis and Vascular Biology, vol. 43, pp. 192–202

Abstract

Ischemic heart disease including myocardial infarction is still the leading cause of death worldwide. Although the survival early after myocardial infarction has been significantly improved by the introduction of percutaneous coronary intervention, long-term morbidity and mortality remain high. The elevated long-term mortality is mainly driven by cardiac remodeling processes triggering ischemic heart failure and electric instability. Despite the new developments in pharmaco-therapy of heart failure, we still lack targeted therapies for cardiac remodeling and fibrosis. Single-cell and genomic technologies allow us to map the human heart at unprecedented resolution and allow to gain insights into cellular and molecular heterogeneity. However, these technologies rely on digested tissue and isolated cells or nuclei and thus lack spatial information. Spatial information is critical to understand tissue homeostasis and disease and can be utilized to identify disease-driving cell populations and mechanisms including cellular cross-talk. Here, we discuss recent advances in single-cell and spatial genomic technologies that give insights into cellular and molecular mechanisms of cardiac remodeling after injury and can be utilized to identify novel therapeutic targets and pave the way toward new therapies in heart failure.

Authors 2

1. David Schumacher Aachen Department of Anesthesiology Institute of Experimental Medicine and Systems Biology Germany. Department of Anesthesiology

   RWTH Aachen University · Universitätsklinikum Aachen

   Affiliation as printed

   Department of Anesthesiology, University Hospital (D.S.), RWTH Aachen University, Germany

   Institute of Experimental Medicine and Systems Biology (D.S., R.K.), RWTH Aachen University, Germany

   David Schumacher https://orcid.org/0000-0002-2308-6543 Institute of Experimental Medicine and Systems Biology (D.S., R.K.), RWTH Aachen University, Germany. Department of Anesthesiology, University Hospital (D.S.), RWTH Aachen University, Germany

2. Rafael Kramann corresponding Aachen Department of Nephrology and Clinical Immunology Institute of Experimental Medicine and Systems Biology

   RWTH Aachen University · Erasmus MC

   Affiliation as printed

   Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, the Netherlands (R.K.)

   Department of Nephrology and Clinical Immunology (R.K.), RWTH Aachen University, Germany

   Institute of Experimental Medicine and Systems Biology (D.S., R.K.), RWTH Aachen University, Germany

   Department of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany