A coupled multiphysics approach for modelling in-stent restenosis
European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS)
Abstract
Drug-eluting stents were developed to counteract the severe restenosis observed after bare-metal stent implantation. The risk of restenosis still prevailed due to the inhibitory effect of the drug on endothelial healing. The current work focuses on extending a multiphysics-based modeling framework to include the effect of anti-inflammatory drugs embedded in the drugeluting stents. An additional advection-reaction-diffusion equation governing the drug transport is introduced herein. Additionally, the effect of drugs, specifically rapamycin-based ones, on the proliferation of smooth muscle cells is captured. An optimal level of drug embedment is realized through the modeling framework.
Authors 4
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Affiliation as printed
RWTH Aachen University , Institute of Applied Mechanics , 52074 Aachen , Germany,
RWTH Aachen University, Institute of Applied Mechanics, 52074 Aachen, Germany,
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Affiliation as printed
RWTH Aachen University , Institute of Applied Mechanics , 52074 Aachen , Germany,
RWTH Aachen University, Institute of Applied Mechanics, 52074 Aachen, Germany,
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Affiliation as printed
RWTH Aachen University , Chair for Computational Analysis of Technical Systems , 52074 Aachen , Germany,
RWTH Aachen University, Chair for Computational Analysis of Technical Systems, 52074 Aachen, Germany,
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Affiliation as printed
RWTH Aachen University , Department of Cardiology, Pneumology, Angiology , and Internal Internsive Medicine , 52074 Aachen , Germany,
RWTH Aachen University, Department of Cardiology, Pneumology, Angiology, and Internal Internsive Medicine, 52074 Aachen, Germany,
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