Identification and Characterization of Corynaridin, a Novel Linaridin from Corynebacterium lactis

Microbiology Spectrum, vol. 11, pp. e0175622

Abstract

has been a hitherto neglected trait, although its species are ubiquitous in nature and make up large parts of the microbiome of humans and animals. In this study, we describe and characterize a novel linaridin family bacteriocin from Corynebacterium lactis and show its narrow-spectrum activity, mainly against other actinobacteria. Moreover, we were able to extend the limited knowledge on linaridin bioactivity in general and for the first time describe the bactericidal activity of such a bacteriocin. Interestingly, the peptide, which was named corynaridin, appears bactericidal, but without formation of pores in the bacterial membrane.

Authors 7

1. Efthimia Pashou

   Universität Ulm

   Affiliation as printed

   Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany

2. Sebastian J. Reich

   Universität Ulm

   Affiliation as printed

   Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany

3. Dominik Weixler

   Universität Ulm

   Affiliation as printed

   Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany

4. Bernhard J. Eikmanns

   Universität Ulm

   Affiliation as printed

   Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany

5. Marco Oldiges Aachen Institute of Biotechnology

   RWTH Aachen University · Forschungszentrum Jülich

   Affiliation as printed

   Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, Jülich, Germany

   Institute of Biotechnology, RWTH Aachen University, Aachen, Germany

6. Christian U. Riedel corresponding

   Universität Ulm

   Affiliation as printed

   Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany

7. Oliver Goldbeck corresponding

   Universität Ulm

   Affiliation as printed

   Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany