Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: An observational study
PLoS ONE, vol. 17, pp. e0266336
Abstract
Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe inflammatory disease in children related to SARS-CoV-2 with multisystem involvement including marked cardiac dysfunction and clinical symptoms that can resemble Kawasaki Disease (KD). We hypothesized that MIS-C and KD might have commonalities as well as unique inflammatory responses and studied these responses in both diseases. In total, fourteen children with MIS-C (n=8) and KD (n=6) were included in the period of March-June 2020. Clinical and routine blood parameters, cardiac follow-up, SARS-CoV-2-specific antibodies and CD4+ T-cell responses, and cytokine-profiles were determined in both groups. In contrast to KD patients, all MIS-C patients had positive Spike protein-specific CD3+CD4+ T-cell responses. MIS-C and KD patients displayed marked hyper-inflammation with high expression of serum cytokines, including the drug-targetable interleukin (IL)-6 and IFN-γ associated chemokines CXCL9, 10 and 11, which decreased at follow-up. No statistical differences were observed between groups. Clinical outcomes were all favourable without cardiac sequelae at 6 months follow-up. In conclusion, MIS-C and KD-patients both displayed cytokine-associated hyper-inflammation with several high levels of drug-targetable cytokines.
Authors 29
-
G. Biesbroek corresponding
Amsterdam UMC Location University of Amsterdam · Emma Kinderziekenhuis
Affiliation as printed
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
-
Amsterdam UMC Location University of Amsterdam · Emma Kinderziekenhuis
Affiliation as printed
Pediatric Intensive Care Unit, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Pediatric Intensive Care Unit, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
-
Amsterdam UMC Location University of Amsterdam · Emma Kinderziekenhuis
Affiliation as printed
Pediatric Cardiology, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Pediatric Cardiology, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
-
Amsterdam UMC Location University of Amsterdam · Emma Kinderziekenhuis
Affiliation as printed
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
-
Amsterdam UMC Location University of Amsterdam · Emma Kinderziekenhuis
Affiliation as printed
Pediatric Intensive Care Unit, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Pediatric Intensive Care Unit, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
-
University Medical Center Utrecht · Wilhelmina Children's Hospital
Affiliation as printed
Department of Pediatric Immunology and Infectious Disease, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Pediatric Immunology and Infectious Disease, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
-
University Medical Center Utrecht · Wilhelmina Children's Hospital
Affiliation as printed
Department of Pediatric Immunology and Infectious Disease, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Pediatric Immunology and Infectious Disease, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
-
Affiliation as printed
Department of Pediatrics, Hilversum, The Netherlands
-
Amsterdam UMC Location University of Amsterdam · Emma Kinderziekenhuis
Affiliation as printed
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
-
Leiden University Medical Center · Willem-Alexander Kinderziekenhuis
Affiliation as printed
Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands
Department of Pediatrics, Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, The Netherlands
-
Leiden University Medical Center · Willem-Alexander Kinderziekenhuis
Affiliation as printed
Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands
Department of Pediatrics, Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, The Netherlands
-
Affiliation as printed
Department of Pediatrics, Medical Spectrum Twente, Enschede, The Netherlands
-
Affiliation as printed
Department of Internal medicine, Gelre Hospital, Apeldoorn, The Netherlands
-
Affiliation as printed
Department of Pediatrics, Spaarne Hospital, Haarlem, The Netherlands
-
Amsterdam UMC Location University of Amsterdam · Emma Kinderziekenhuis
Affiliation as printed
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
-
Amsterdam UMC Location University of Amsterdam · Emma Kinderziekenhuis
Affiliation as printed
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
-
Amsterdam UMC Location University of Amsterdam · Emma Kinderziekenhuis
Affiliation as printed
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
-
Amsterdam UMC Location University of Amsterdam · Emma Kinderziekenhuis
Affiliation as printed
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
-
Erasmus MC - Sophia Children’s Hospital
Affiliation as printed
Department of Pediatric Surgery and Intensive Care, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands
Department of Pediatric Surgery and Intensive Care, Erasmus Medical Center, Sophia Children’s Hospital, Rotterdam, The Netherlands
-
Leiden University Medical Center · Willem-Alexander Kinderziekenhuis
Affiliation as printed
Pediatric Intensive Care Unit, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands
Pediatric Intensive Care Unit, Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, The Netherlands
-
Amsterdam UMC Location University of Amsterdam · Emma Kinderziekenhuis
Affiliation as printed
Department of Pediatric Pulmonology, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatrics, Hilversum, The Netherlands
Department of Pediatric Pulmonology, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
-
Sanquin · University of Amsterdam
Affiliation as printed
Department of Virology, Sanquin Research Institute, University of Amsterdam, Amsterdam, The Netherlands
-
Sanquin · University of Amsterdam
Affiliation as printed
Department of Blood Cell Research, Sanquin Research Institute, University of Amsterdam, Amsterdam, The Netherlands
-
Amsterdam UMC Location University of Amsterdam · Emma Kinderziekenhuis
Affiliation as printed
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
-
Leiden University Medical Center · Willem-Alexander Kinderziekenhuis
Affiliation as printed
Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands
Department of Pediatrics, Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, The Netherlands
-
Amsterdam UMC Location University of Amsterdam · Sanquin · Emma Kinderziekenhuis · University of Amsterdam
Affiliation as printed
Department of Blood Cell Research, Sanquin Research Institute, University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children’s Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
Cited by 4 stored of 4
4 results
No patents citing this paper on Lens.org (checked 2026-10-11).