Cell-penetrating peptide-conjugated copper complexes for redox-mediated anticancer therapy

Frontiers in Pharmacology, vol. 13, pp. 1060827

Abstract

CPP-conjugation promoted an enhanced anticancer activity, already detectable at short treatment times. Additionally, immunofluorescence assays show that the Cu(II) peptide-conjugate distributed throughout the cytosol without lysosomal colocalization, suggesting potential avoidance of endosomal entrapment. Overall, the systematic exploration of the tailored modifications enables us to provide further understanding on structure-activity relationships of redox-active metal-based (Cu(II)) cytotoxic complexes, which contributes to rationalize and improve the design of more efficient redox-mediated metal-based anticancer therapy.

Authors 8

1. Quim Peña Aachen Institute for Experimental Molecular Imaging Department of Nanomedicine and Theranostics Faculty of Medicine

   RWTH Aachen University · Universitätsklinikum Aachen · Centre National de la Recherche Scientifique · Aix-Marseille Université · Universitat Autònoma de Barcelona · Centrale Méditerranée · Institut des Sciences Moléculaires de Marseille

   Affiliation as printed

   Aix Marseille University, CNRS, Centrale Marseille, ISm2, Marseille, France

   Departament de Química, Facultat de Ciències, Universitat Autònoma de Barcelona, Barcelona, Spain

   Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Faculty of Medicine, RWTH Aachen University Clinic, Aachen, Germany

2. Sergi Rodríguez-Calado

   Universitat Autònoma de Barcelona

   Affiliation as printed

   Department Bioquímica i Biologia Molecular, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain

3. Ariane Jalila Simaan

   Centre National de la Recherche Scientifique · Aix-Marseille Université · Centrale Méditerranée · Institut des Sciences Moléculaires de Marseille

   Affiliation as printed

   Aix Marseille University, CNRS, Centrale Marseille, ISm2, Marseille, France

4. Mercè Capdevila

   Universitat Autònoma de Barcelona

   Affiliation as printed

   Departament de Química, Facultat de Ciències, Universitat Autònoma de Barcelona, Barcelona, Spain

5. Pau Bayón

   Universitat Autònoma de Barcelona

   Affiliation as printed

   Departament de Química, Facultat de Ciències, Universitat Autònoma de Barcelona, Barcelona, Spain

6. Òscar Palacios

   Universitat Autònoma de Barcelona

   Affiliation as printed

   Departament de Química, Facultat de Ciències, Universitat Autònoma de Barcelona, Barcelona, Spain

7. Júlia Lorenzo corresponding

   Universitat Autònoma de Barcelona

   Affiliation as printed

   Department Bioquímica i Biologia Molecular, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain

8. Olga Iranzo corresponding

   Centre National de la Recherche Scientifique · Aix-Marseille Université · Centrale Méditerranée · Institut des Sciences Moléculaires de Marseille

   Affiliation as printed

   Aix Marseille University, CNRS, Centrale Marseille, ISm2, Marseille, France