Plant extracts and compounds for combating schistosomiasis

Phytochemistry Reviews, vol. 22, pp. 1691–1806

Abstract

Abstract Schistosomiasis is a vector-borne water-based disease caused by Schistosoma blood flukes. It mostly affects people in low-income regions, 90% of reported cases being in developing countries. Schistosoma has a complex lifecycle, alternately infecting mammalian hosts and snails. The snails hosting the parasite are the most viable targets. Selective preparations for reducing the parasite pool in snails and infected water are required as current molluscicides are also nontoxic to other organisms, including fish, and thus affect food supplies in infected areas. Plants (e.g. Annona crassiflora Mart., A. muricata L., and A. montana Macfad.) are attractive potential sources as alternative molluscicides and novel entity to treat the disease owned to their diverse biologically potent compounds including; saponins, alkaloids, terpenoids, and tannins. Additionally, they can be locally cultivated, providing income for farmers and reducing treatment costs. Here, we review plants, plant extracts and isolated compounds that have shown activities against the host snails or Schistosoma in various parts of its life cycle. Plants have a lot of potential and will continue to contribute feasible, effective medicines and/or pesticides; more research is warranted to fully explore their future applications. Graphical abstract

Authors 13

1. Hesham R. El‐Seedi corresponding

   Jiangsu University · Uppsala University · Jiangsu Education Department · Menoufia University

   Affiliation as printed

   Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, 32512, Egypt

   International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing (Jiangsu Education Department), Zhenjiang, 212013, China

   International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China

   Pharmacognosy Group, Department of Pharmaceutical Biosciences, Biomedical Centre, Uppsala University, Box 591, 751 24, Uppsala, Sweden

2. Shaden A. M. Khalifa

   Stockholm University

   Affiliation as printed

   Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 91, Stockholm, Sweden

3. Azza Hassan Mohamed

   Menoufia University

   Affiliation as printed

   Division of Parasitology, Department of Zoology, Faculty of Science, Menoufia University, Shebin El-Kom, 32512, Egypt

4. Nermeen Yosri

   Beni-Suef University · Jiangsu University

   Affiliation as printed

   Chemistry Department of Medicinal and Aromatic Plants, Research Institute of Medicinal and Aromatic Plants (RIMAP), Beni-Suef University, Beni-Suef, 62514, Egypt

   School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China

5. Chao Zhao

   Fujian Agriculture and Forestry University

   Affiliation as printed

   College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China

6. Nabil E. El-Wakeil

   National Research Centre · King Faisal University

   Affiliation as printed

   Dept. of Arid Land Agriculture, College of Agri. & Food Sciences, King Faisal University, P.O Box 55073, Hofuf 31982, Saudi Arabia

   Pests and Plant Protection Department, National Research Centre, Dokki, Cairo, Egypt

7. Nour Fathi Attia

   National Institute of Standards

   Affiliation as printed

   Gas Analysis and Fire Safety Laboratory, Chemistry Division, National Institute of Standards, 136, Giza, 12211, Egypt

8. Baojun Xu

   Beijing Normal-Hong Kong Baptist University

   Affiliation as printed

   Programme of Food Science and Technology, BNU-HKBU United International College, Zhuhai, China

9. AbdElhafez R. AbdElhafez

   Menoufia University

   Affiliation as printed

   Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, 32512, Egypt

10. Mohammad Hossein Boskabady

    Mashhad University of Medical Sciences

    Affiliation as printed

    Deartment of Physiology, School of Medicine, Mashhad, 9177948564, Iran

11. Sherif Elseedy

    Ain Shams University

    Affiliation as printed

    Faculty of Medicine, Ain Shams University, Cairo, 11591, Egypt

12. Thomas Efferth

    Johannes Gutenberg University Mainz

    Affiliation as printed

    Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany

13. Robert Verpoorte Aachen Natural Products Laboratory Institute of Biology, Leiden University

    Leiden University

    Affiliation as printed

    Natural Products Laboratory, Institute of Biology, Leiden University, Box 955, 2300RA, Leiden, The Netherlands