Nanofibrous Hydrogel Nanocomposite Based on Strontium-Doped Bioglass Nanofibers for Bone Tissue Engineering Applications

Biology, vol. 11, pp. 1472

Abstract

The main aim of the current study is to fabricate an osteocompatible, bioactive, porous, and degradable bone tissue engineering scaffold. For this purpose, bioactive glasses (BGs) were chosen due to their similarity to bone's natural mineral composition, and the effect of replacing Ca ions with Sr on their properties were considered. First, strontium-containing BGs (Sr-BGs) were synthesized using the electrospinning technique and assembled by the sol-gel method, then they were incorporated into the alginate (Alg) matrix. Photographs of the scanning electron microscope (SEM) showed that the BG nanofibers have a diameter of 220 ± 36 nm, which was smaller than the precursor nanofibers (275 ± 66 nm). The scaffolds possess a porous internal microstructure (230-330 nm pore size) with interconnected pores. We demonstrated that the scaffolds could be degraded in the acetate sodium buffer and phosphate-buffered saline. The osteoactivity of the scaffolds was confirmed via visual inspection of the SEM illustrations after seven days of immersing them in the SBF solution. In vitro assessments disclosed that the produced Alg-based composites including Sr-BGs (Alg/Sr-BGs) are blood-compatible and biocompatible. Accumulating evidence shows that Alg/Sr-BG (5%, 10%, and 15%) hydrogels could be a promising scaffold for bone regeneration.

Authors 6

1. Soheila Zare

   Zanjan University of Medical Sciences

   Affiliation as printed

   Student Research Committee, Zanjan University of Medical Sciences, Zanjan 45154, Iran

2. Mahnaz Mohammadpour

   Tarbiat Modares University

   Affiliation as printed

   Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, Tehran 1411713116, Iran

3. Zhila Izadi

   Kermanshah University of Medical Sciences

   Affiliation as printed

   Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah P.O. Box 671551616, Iran

   USERN Office, Kermanshah University of Medical Sciences, Kermanshah P.O. Box 671551616, Iran

4. Samaneh Ghazanfari Aachen Department of Biohybrid and Medical Textiles (BioTex)

   RWTH Aachen University · Maastricht University

   Affiliation as printed

   Aachen-Maastricht Institute for Biobased Materials (AMIBM), Faculty of Science and Engineering, Maastricht University, 6167 RD Geleen, The Netherlands

   Department of Biohybrid and Medical Textiles (BioTex), AME-Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, 52072 Aachen, Germany

5. Samad Nadri corresponding

   Zanjan University of Medical Sciences

   Affiliation as printed

   Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan 45154, Iran

   Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 45154, Iran

6. Hadi Samadian corresponding

   Hamedan University of Medical Sciences

   Affiliation as printed

   Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan 6517838736, Iran