CKD Effects on Platelets: Implications for Cardiovascular Risk

Kidney International Reports, vol. 7, pp. 2126–2128

Abstract

Platelets are crucial to prevent and stop bleeding, a process referred to as hemostasis. They do so by adhering to the damaged vascular wall, triggering platelet activation and the subsequent growth of a thrombus through an increasing accumulation of platelets and thrombin-generated fibrin. Platelets, however, also contribute to the occurrence of cardiovascular events by stimulating the formation and progression of atherosclerotic lesions and through their crucial involvement in the formation of thrombi triggered by vascular dysfunction, atherosclerotic plaque rupture, or plaque erosion.

Authors 3

1. Constance C. F. M. J. Baaten Aachen Institute for Molecular Cardiovascular Research

   RWTH Aachen University · Universitätsklinikum Aachen · Maastricht University

   Affiliation as printed

   Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands

   Institute for Molecular Cardiovascular Research (IMCAR), University Hospital RWTH Aachen, Aachen, Germany

2. Claudio Rigatto

   University of Manitoba · Seven Oaks General Hospital

   Affiliation as printed

   Chronic Disease Innovation Centre, Seven Oaks General Hospital, Winnipeg, Manitoba, Canada

   Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

3. Heidi Noels corresponding Aachen Institute for Molecular Cardiovascular Research

   RWTH Aachen University · Universitätsklinikum Aachen · Maastricht University

   Affiliation as printed

   Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands

   Institute for Molecular Cardiovascular Research (IMCAR), University Hospital RWTH Aachen, Aachen, Germany