Incorporating progesterone receptor expression into the PREDICT breast prognostic model
European Journal of Cancer, vol. 173, pp. 178–193
Abstract
Background Predict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast cancer. The aim of this study was to incorporate the prognostic effect of progesterone receptor (PR) status into a new version of PREDICT and to compare its performance to the current version (2.2). Method The prognostic effect of PR status was based on the analysis of data from 45,088 European patients with breast cancer from 49 studies in the Breast Cancer Association Consortium. Cox proportional hazard models were used to estimate the hazard ratio for PR status. Data from a New Zealand study of 11,365 patients with early invasive breast cancer were used for external validation. Model calibration and discrimination were used to test the model performance. Results Having a PR-positive tumour was associated with a 23% and 28% lower risk of dying from breast cancer for women with oestrogen receptor (ER)-negative and ER-positive breast cancer, respectively. The area under the ROC curve increased with the addition of PR status from 0.807 to 0.809 for patients with ER-negative tumours ( p = 0.023) and from 0.898 to 0.902 for patients with ER-positive tumours ( p = 2.3 × 10 −6 ) in the New Zealand cohort. Model calibration was modest with 940 observed deaths compared to 1151 predicted. Conclusion The inclusion of the prognostic effect of PR status to PREDICT Breast has led to an improvement of model performance and more accurate absolute treatment benefit predictions for individual patients. Further studies should determine whether the baseline hazard function requires recalibration.
Authors 100
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Isabelle Grootes corresponding
Affiliation as printed
University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, CB1 8RN, UK. Electronic address: ig345@medschl.cam.ac.uk
University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, CB1 8RN, UK
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The Netherlands Cancer Institute
Affiliation as printed
The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, 1066 CX, the Netherlands
The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, 1066 CX, the Netherlands
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Affiliation as printed
University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, CB1 8RN, UK
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The University of Melbourne · Cancer Council Victoria · Monash Health · Monash University
Affiliation as printed
Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, Victoria, 3004, Australia; The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, Victoria, 3010, Australia; Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, Victoria, 3168, Australia
Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, Victoria, 3004, Australia
Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, Victoria, 3168, Australia
The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, Victoria, 3010, Australia
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The University of Melbourne · Cancer Council Victoria · Monash Health · Monash University
Affiliation as printed
Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, Victoria, 3004, Australia; The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, Victoria, 3010, Australia; Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, Victoria, 3168, Australia
Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, Victoria, 3004, Australia
Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, Victoria, 3168, Australia
The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, Victoria, 3010, Australia
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Affiliation as printed
The Institute of Cancer Research, Division of Genetics and Epidemiology, London, SM2 5NG, UK; The Institute of Cancer Research, Division of Breast Cancer Research, London, SW7 3RP, UK
The Institute of Cancer Research, Division of Breast Cancer Research, London, SW7 3RP, UK
The Institute of Cancer Research, Division of Genetics and Epidemiology, London, SM2 5NG, UK
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University of California, Los Angeles · Friedrich-Alexander-Universität Erlangen-Nürnberg · Universitätsklinikum Erlangen · Comprehensive Cancer Center Erlangen
Affiliation as printed
University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, Los Angeles, CA, 90095, USA; Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Department of Gynecology and Obstetrics, Erlangen, 91054, Germany
Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Department of Gynecology and Obstetrics, Erlangen, 91054, Germany
University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, Los Angeles, CA, 90095, USA
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National Institutes of Health · National Cancer Institute · Division of Cancer Epidemiology and Genetics
Affiliation as printed
National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Bethesda, MD, 20850, USA
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Mount Sinai Hospital · University of Toronto · Lunenfeld-Tanenbaum Research Institute
Affiliation as printed
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON, M5G 1X5, Canada; University of Toronto, Department of Molecular Genetics, Toronto, ON, M5S 1A8, Canada
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON, M5G 1X5, Canada
University of Toronto, Department of Molecular Genetics, Toronto, ON, M5S 1A8, Canada
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University of California, Irvine
Affiliation as printed
University of California Irvine, Department of Medicine, Genetic Epidemiology Research Institute, Irvine, CA, 92617, USA
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Friedrich-Alexander-Universität Erlangen-Nürnberg · Universitätsklinikum Erlangen · Comprehensive Cancer Center Erlangen
Affiliation as printed
Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Department of Gynecology and Obstetrics, Erlangen, 91054, Germany
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University of Helsinki · Helsinki University Hospital · Örebro University Hospital
Affiliation as printed
University of Helsinki, Department of Oncology, Helsinki University Hospital, Helsinki, 00290, Finland; Örebro University Hospital, Department of Oncology, Örebro, 70185, Sweden
University of Helsinki, Department of Oncology, Helsinki University Hospital, Helsinki, 00290, Finland
Örebro University Hospital, Department of Oncology, Örebro, 70185, Sweden
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University of Copenhagen · Herlev Hospital · Copenhagen University Hospital · Gentofte Hospital
Affiliation as printed
Copenhagen University Hospital, Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev, 2730, Denmark; Copenhagen University Hospital, Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, 2730, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, 2200, Denmark
Copenhagen University Hospital, Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev, 2730, Denmark
Copenhagen University Hospital, Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, 2730, Denmark
University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, 2200, Denmark
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Affiliation as printed
University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, CB1 8RN, UK
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European Institute of Oncology
Affiliation as printed
IEO, European Institute of Oncology IRCCS, Division of Cancer Prevention and Genetics, Milan, 20141, Italy
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Affiliation as printed
Universidad de La Sabana, Medical Faculty, Bogota, 140013, Colombia
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German Cancer Research Center · Heidelberg University
Affiliation as printed
German Cancer Research Center (DKFZ), Molecular Epidemiology Group, C080, Heidelberg, 69120, Germany; University of Heidelberg, Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, Heidelberg, 69120, Germany
German Cancer Research Center (DKFZ), Molecular Epidemiology Group, C080, Heidelberg, 69120, Germany
University of Heidelberg, Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, Heidelberg, 69120, Germany
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University of Utah · Huntsman Cancer Institute
Affiliation as printed
University of Utah, Department of Internal Medicine and Huntsman Cancer Institute, Salt Lake City, UT, 84112, USA
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Affiliation as printed
Instituto de Investigación Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Oncology and Genetics Unit, Vigo, 36312, Spain
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Affiliation as printed
Seoul National University Graduate School, Department of Biomedical Sciences, Seoul, 03080, South Korea; Seoul National University, Cancer Research Institute, Seoul, 03080, South Korea; Seoul National University Medical Research Center, Institute of Health Policy and Management, Seoul, 03080, South Korea
Seoul National University Graduate School, Department of Biomedical Sciences, Seoul, 03080, South Korea
Seoul National University Medical Research Center, Institute of Health Policy and Management, Seoul, 03080, South Korea
Seoul National University, Cancer Research Institute, Seoul, 03080, South Korea
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The University of Sydney · Westmead Institute for Medical Research
Affiliation as printed
University of Sydney, Westmead Institute for Medical Research, Sydney, New South Wales, 2145, Australia
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Affiliation as printed
Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN, 55905, USA
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Affiliation as printed
University of Sheffield, Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, Sheffield, S10 2TN, UK
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Affiliation as printed
University of Sheffield, Academic Unit of Pathology, Department of Neuroscience, Sheffield, S10 2TN, UK
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Affiliation as printed
Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, 171 65, Sweden
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Leiden University Medical Center
Affiliation as printed
Leiden University Medical Center, Department of Pathology, Leiden, 2333 ZA, the Netherlands; Leiden University Medical Center, Department of Human Genetics, Leiden, 2333 ZA, the Netherlands
Leiden University Medical Center, Department of Human Genetics, Leiden, 2333 ZA, the Netherlands
Leiden University Medical Center, Department of Pathology, Leiden, 2333 ZA, the Netherlands
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Medizinische Hochschule Hannover
Affiliation as printed
Hannover Medical School, Gynaecology Research Unit, Hannover, 30625, Germany
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Affiliation as printed
University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, CB1 8RN, UK
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Affiliation as printed
University of Westminster, School of Life Sciences, London, W1B 2HW, UK
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Affiliation as printed
University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, CB1 8RN, UK; University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, CB1 8RN, UK
University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, CB1 8RN, UK
University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, CB1 8RN, UK
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Affiliation as printed
University of Southampton, Faculty of Medicine, Southampton, SO17 1BJ, UK
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Affiliation as printed
Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, 171 65, Sweden
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Affiliation as printed
University Hospital Ulm, Department of Gynaecology and Obstetrics, Ulm, 89075, Germany
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Manchester Academic Health Science Centre · University of Manchester · St Mary's Hospital · Manchester University NHS Foundation Trust
Affiliation as printed
University of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, M13 9WL, UK; St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, Manchester, M13 9WL, UK
St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, Manchester, M13 9WL, UK
University of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, M13 9WL, UK
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National Institutes of Health · Edinburgh Cancer Research · National Cancer Institute · Division of Cancer Epidemiology and Genetics · University of Edinburgh
Affiliation as printed
National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Bethesda, MD, 20850, USA; The University of Edinburgh, Usher Institute of Population Health Sciences and Informatics, Edinburgh, EH16 4UX, UK; The University of Edinburgh, Cancer Research UK Edinburgh Centre, Edinburgh, EH4 2XR, UK
National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Bethesda, MD, 20850, USA
The University of Edinburgh, Cancer Research UK Edinburgh Centre, Edinburgh, EH4 2XR, UK
The University of Edinburgh, Usher Institute of Population Health Sciences and Informatics, Edinburgh, EH16 4UX, UK
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Affiliation as printed
University Hospital Ulm, Department of Gynaecology and Obstetrics, Ulm, 89075, Germany
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Universitair Ziekenhuis Leuven
Affiliation as printed
Leuven Cancer Institute, University Hospitals Leuven, Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven, 3000, Belgium
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Affiliation as printed
Peter MacCallum Cancer Center, Melbourne, Victoria, Australia, 3000
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Affiliation as printed
Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, 171 65, Sweden
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University of California San Diego · Complejo Hospitalario Universitario de Santiago · Fundación Pública Galega de Medicina Xenómica · Instituto de Investigación Sanitaria de Santiago · Servicio Gallego de Salud · Moores Cancer Center
Affiliation as printed
Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, 15706, Spain; University of California San Diego, Moores Cancer Center, La Jolla, CA, 92037, USA
Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, 15706, Spain
University of California San Diego, Moores Cancer Center, La Jolla, CA, 92037, USA
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Hospital Clínico San Carlos · Instituto de Investigación Sanitaria del Hospital Clínico San Carlos · Centro de Investigación Biomédica en Red de Cáncer
Affiliation as printed
Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Medical Oncology Department, Hospital Clínico San Carlos, Madrid, 28040, Spain
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Spanish National Cancer Research Centre
Affiliation as printed
Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, 28029, Spain
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Friedrich-Alexander-Universität Erlangen-Nürnberg · Universitätsklinikum Erlangen · Comprehensive Cancer Center Erlangen
Affiliation as printed
Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Department of Gynecology and Obstetrics, Erlangen, 91054, Germany
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University of Southern California
Affiliation as printed
University of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, 90033, USA
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Karolinska Institutet · Stockholm South General Hospital
Affiliation as printed
Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, 171 65, Sweden; Södersjukhuset, Department of Oncology, Stockholm, 118 83, Sweden
Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, 171 65, Sweden
Södersjukhuset, Department of Oncology, Stockholm, 118 83, Sweden
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Affiliation as printed
German Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, 69120, Germany
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Manchester Academic Health Science Centre · University of Manchester · Manchester University NHS Foundation Trust · Wythenshawe Hospital · NIHR Manchester Biomedical Research Centre
Affiliation as printed
University of Manchester, Manchester Academic Health Science Centre, Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, Manchester, M13 9PT, UK; Wythenshawe Hospital, Manchester University NHS Foundation Trust, Nightingale & Genesis Prevention Centre, Manchester, M23 9LT, UK; Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Unit, Manchester, M13 9WL, UK
Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Unit, Manchester, M13 9WL, UK
University of Manchester, Manchester Academic Health Science Centre, Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, Manchester, M13 9PT, UK
Wythenshawe Hospital, Manchester University NHS Foundation Trust, Nightingale & Genesis Prevention Centre, Manchester, M23 9LT, UK
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National University of Singapore · National University Health System
Affiliation as printed
National University of Singapore and National University Health System, Saw Swee Hock School of Public Health, Singapore, 119077, Singapore; National University Health System, Department of Surgery, Singapore, 119228, Singapore
National University Health System, Department of Surgery, Singapore, 119228, Singapore
National University of Singapore and National University Health System, Saw Swee Hock School of Public Health, Singapore, 119077, Singapore
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Friedrich-Alexander-Universität Erlangen-Nürnberg · Universitätsklinikum Erlangen · Comprehensive Cancer Center Erlangen
Affiliation as printed
Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Department of Gynecology and Obstetrics, Erlangen, 91054, Germany
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Affiliation as printed
Erasmus MC Cancer Institute, Department of Medical Oncology, Rotterdam, 3015 GD, the Netherlands
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Kaohsiung Municipal Hsiao-Kang Hospital
Affiliation as printed
Kaohsiung Municipal Hsiao-Kang Hospital, Department of Surgery, Kaohsiung, 812, Taiwan
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Affiliation as printed
University of Manchester, Division of Cancer Sciences, Manchester, M13 9PL, UK
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Aichi Cancer Center · Nagoya University
Affiliation as printed
Aichi Cancer Center Research Institute, Division of Cancer Information and Control, Nagoya, 464-8681, Japan; Nagoya University Graduate School of Medicine, Division of Cancer Epidemiology, Nagoya, 466-8550, Japan
Aichi Cancer Center Research Institute, Division of Cancer Information and Control, Nagoya, 464-8681, Japan
Nagoya University Graduate School of Medicine, Division of Cancer Epidemiology, Nagoya, 466-8550, Japan
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Affiliation as printed
Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, 71-252, Poland; Pomeranian Medical University, Independent Laboratory of Molecular Biology and Genetic Diagnostics, Szczecin, 71-252, Poland
Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, 71-252, Poland
Pomeranian Medical University, Independent Laboratory of Molecular Biology and Genetic Diagnostics, Szczecin, 71-252, Poland
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Affiliation as printed
University Hospital Ulm, Department of Gynaecology and Obstetrics, Ulm, 89075, Germany
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Stanford Medicine · Stanford Cancer Institute · Stanford University
Affiliation as printed
Stanford University School of Medicine, Department of Epidemiology & Population Health, Stanford, CA, 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Department of Medicine, Division of Oncology, Stanford, CA, 94304, USA
Stanford Cancer Institute, Stanford University School of Medicine, Department of Medicine, Division of Oncology, Stanford, CA, 94304, USA
Stanford University School of Medicine, Department of Epidemiology & Population Health, Stanford, CA, 94305, USA
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Affiliation as printed
German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, 69120, Germany
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Affiliation as printed
Seoul National University, Cancer Research Institute, Seoul, 03080, South Korea; Seoul National University College of Medicine, Department of Preventive Medicine, Seoul, 03080, South Korea
Seoul National University College of Medicine, Department of Preventive Medicine, Seoul, 03080, South Korea
Seoul National University, Cancer Research Institute, Seoul, 03080, South Korea
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Oslo University Hospital · University of Oslo
Affiliation as printed
Oslo University Hospital and University of Oslo, Department of Medical Genetics, Oslo, 0379, Norway; University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo, 0450, Norway
Oslo University Hospital and University of Oslo, Department of Medical Genetics, Oslo, 0379, Norway
University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo, 0450, Norway
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Hong Kong Sanatorium and Hospital · University of Hong Kong
Affiliation as printed
Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong; The University of Hong Kong, Department of Surgery, Hong Kong; Hong Kong Sanatorium and Hospital, Department of Surgery and Cancer Genetics Center, Hong Kong
Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong
Hong Kong Sanatorium and Hospital, Department of Surgery and Cancer Genetics Center, Hong Kong
The University of Hong Kong, Department of Surgery, Hong Kong
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VIB-KU Leuven Center for Cancer Biology · KU Leuven
Affiliation as printed
VIB Center for Cancer Biology, VIB, Leuven, 3001, Belgium; University of Leuven, Laboratory for Translational Genetics, Department of Human Genetics, Leuven, 3000, Belgium
University of Leuven, Laboratory for Translational Genetics, Department of Human Genetics, Leuven, 3000, Belgium
VIB Center for Cancer Biology, VIB, Leuven, 3001, Belgium
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Affiliation as printed
Genome Institute of Singapore, Human Genetics Division, Singapore, 138672, Singapore
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Affiliation as printed
Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, 71-252, Poland
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Affiliation as printed
German Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, 69120, Germany
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Karolinska Institutet · Stockholm South General Hospital
Affiliation as printed
Södersjukhuset, Department of Oncology, Stockholm, 118 83, Sweden; Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, 118 83, Sweden
Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, 118 83, Sweden
Södersjukhuset, Department of Oncology, Stockholm, 118 83, Sweden
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Aichi Cancer Center · Nagoya University
Affiliation as printed
Nagoya University Graduate School of Medicine, Division of Cancer Epidemiology, Nagoya, 466-8550, Japan; Aichi Cancer Center Research Institute, Division of Cancer Epidemiology and Prevention, Nagoya, 464-8681, Japan
Aichi Cancer Center Research Institute, Division of Cancer Epidemiology and Prevention, Nagoya, 464-8681, Japan
Nagoya University Graduate School of Medicine, Division of Cancer Epidemiology, Nagoya, 466-8550, Japan
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Affiliation as printed
University of Malaya, Department of Surgery, Faculty of Medicine, Kuala Lumpur, 50603, Malaysia
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University Health Network · University of Toronto
Affiliation as printed
University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, M5S 1A8, Canada; University Health Network, Laboratory Medicine Program, Toronto, ON, M5G 2C4, Canada
University Health Network, Laboratory Medicine Program, Toronto, ON, M5G 2C4, Canada
University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, M5S 1A8, Canada
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University of Helsinki · Helsinki University Hospital
Affiliation as printed
University of Helsinki, Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, 00290, Finland
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Manchester Academic Health Science Centre · University of Manchester · St Mary's Hospital · Manchester University NHS Foundation Trust
Affiliation as printed
University of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, M13 9WL, UK; St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, Manchester, M13 9WL, UK
St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, Manchester, M13 9WL, UK
University of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, M13 9WL, UK
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Memorial Sloan Kettering Cancer Center
Affiliation as printed
Memorial Sloan Kettering Cancer Center, Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, New York, NY, 10065, USA; Memorial Sloan Kettering Cancer Center, Clinical Genetics Service, Department of Medicine, New York, NY, 10065, USA
Memorial Sloan Kettering Cancer Center, Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, New York, NY, 10065, USA
Memorial Sloan Kettering Cancer Center, Clinical Genetics Service, Department of Medicine, New York, NY, 10065, USA
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Spanish National Cancer Research Centre · Centre for Biomedical Network Research on Rare Diseases
Affiliation as printed
Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, 28029, Spain; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, 28029, Spain
Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, 28029, Spain
Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, 28029, Spain
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Affiliation as printed
Seoul National University, Cancer Research Institute, Seoul, 03080, South Korea; Seoul National University College of Medicine, Department of Preventive Medicine, Seoul, 03080, South Korea; Seoul National University College of Medicine, Integrated Major in Innovative Medical Science, Seoul, 03080, South Korea
Seoul National University College of Medicine, Department of Preventive Medicine, Seoul, 03080, South Korea
Seoul National University College of Medicine, Integrated Major in Innovative Medical Science, Seoul, 03080, South Korea
Seoul National University, Cancer Research Institute, Seoul, 03080, South Korea
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Medizinische Hochschule Hannover
Affiliation as printed
Hannover Medical School, Gynaecology Research Unit, Hannover, 30625, Germany
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Affiliation as printed
American Cancer Society, Department of Population Science, Atlanta, GA, 30303, USA
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Affiliation as printed
University of Westminster, School of Life Sciences, London, W1B 2HW, UK
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Affiliation as printed
University of Oulu, Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, Oulu, 90570, Finland; Northern Finland Laboratory Centre Oulu, Laboratory of Cancer Genetics and Tumor Biology, Oulu, 90570, Finland
Northern Finland Laboratory Centre Oulu, Laboratory of Cancer Genetics and Tumor Biology, Oulu, 90570, Finland
University of Oulu, Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, Oulu, 90570, Finland
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Affiliation as printed
University Hospital Ulm, Department of Gynaecology and Obstetrics, Ulm, 89075, Germany
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Fondazione IRCCS Istituto Nazionale dei Tumori
Affiliation as printed
Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Milan, 20133, Italy
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Technion – Israel Institute of Technology · Carmel Medical Center · Clalit Health Services
Affiliation as printed
Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, 35254, Israel
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Hospital Universitario Puerta de Hierro Majadahonda
Affiliation as printed
Hospital Universitario Puerta de Hierro, Medical Oncology Department, Madrid, 28222, Spain
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University Hospital of Larissa
Affiliation as printed
University Hospital of Larissa, Department of Oncology, Larissa, 411 10, Greece
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Affiliation as printed
King's College London, School of Cancer & Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, London, UK
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German Cancer Research Center · Heidelberg University · National Center for Tumor Diseases
Affiliation as printed
University of Heidelberg, Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, Heidelberg, 69120, Germany; University Hospital and German Cancer Research Center, National Center for Tumor Diseases, Heidelberg, 69120, Germany
University Hospital and German Cancer Research Center, National Center for Tumor Diseases, Heidelberg, 69120, Germany
University of Heidelberg, Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, Heidelberg, 69120, Germany
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Affiliation as printed
University Hospital Ulm, Department of Gynaecology and Obstetrics, Ulm, 89075, Germany
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Affiliation as printed
The Institute of Cancer Research, Division of Genetics and Epidemiology, London, SM2 5NG, UK
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China Medical University · Institute of Biomedical Sciences, Academia Sinica · Academia Sinica
Affiliation as printed
Academia Sinica, Institute of Biomedical Sciences, Taipei, 115, Taiwan; China Medical University, School of Public Health, Taichung, Taiwan
Academia Sinica, Institute of Biomedical Sciences, Taipei, 115, Taiwan
China Medical University, School of Public Health, Taichung, Taiwan
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Technion – Israel Institute of Technology · Carmel Medical Center · Clalit Health Services
Affiliation as printed
Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, 35254, Israel
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University Hospital Heidelberg
Affiliation as printed
University Hospital Heidelberg, Department of Pathology, Institute of Pathology, Heidelberg, 69120, Germany
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Affiliation as printed
University of Southampton, Faculty of Medicine, Southampton, SO17 1BJ, UK
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Affiliation as printed
University of Auckland, Auckland, New Zealand
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University of Malaya · Cancer Research Malaysia
Affiliation as printed
University of Malaya, Department of Surgery, Faculty of Medicine, Kuala Lumpur, 50603, Malaysia; Cancer Research Malaysia, Breast Cancer Research Programme, Subang Jaya, Selangor, 47500, Malaysia
Cancer Research Malaysia, Breast Cancer Research Programme, Subang Jaya, Selangor, 47500, Malaysia
University of Malaya, Department of Surgery, Faculty of Medicine, Kuala Lumpur, 50603, Malaysia
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Affiliation as printed
American Cancer Society, Department of Population Science, Atlanta, GA, 30303, USA
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German Cancer Research Center · Pontificia Universidad Javeriana
Affiliation as printed
German Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, 69120, Germany; Pontificia Universidad Javeriana, Institute of Human Genetics, Bogota, 110231, Colombia
German Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, 69120, Germany
Pontificia Universidad Javeriana, Institute of Human Genetics, Bogota, 110231, Colombia
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Affiliation as printed
Mayo Clinic, Department of Quantitative Health Sciences, Division of Epidemiology, Rochester, MN, 55905, USA
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Affiliation as printed
Erasmus University Medical Center, Department of Pathology, Rotterdam, 3015 CN, the Netherlands
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Karolinska Institutet · Stockholm South General Hospital
Affiliation as printed
Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, 118 83, Sweden
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University of Utah · Huntsman Cancer Institute
Affiliation as printed
University of Utah, Department of Internal Medicine and Huntsman Cancer Institute, Salt Lake City, UT, 84112, USA
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Affiliation as printed
University of Oulu, Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, Oulu, 90570, Finland; Northern Finland Laboratory Centre Oulu, Laboratory of Cancer Genetics and Tumor Biology, Oulu, 90570, Finland
Northern Finland Laboratory Centre Oulu, Laboratory of Cancer Genetics and Tumor Biology, Oulu, 90570, Finland
University of Oulu, Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, Oulu, 90570, Finland
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Affiliation as printed
University of Auckland, Auckland, New Zealand
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