A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking
Nature Aging, vol. 2, pp. 644–661
Authors 27
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Albert Higgins‐Chen corresponding
Yale University · VA Connecticut Healthcare System
Affiliation as printed
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
VA Connecticut Healthcare System, West Haven, CT, USA
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Affiliation as printed
Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA
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Affiliation as printed
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Affiliation as printed
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
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Affiliation as printed
Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA
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Affiliation as printed
Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA
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Affiliation as printed
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
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Columbia University Irving Medical Center · New York State Psychiatric Institute
Affiliation as printed
Departments of Psychiatry and Neurology, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, United States
New York State Psychiatric Institute, New York, NY United States
Departments of Psychiatry and Neurology, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA
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University of California, San Francisco
Affiliation as printed
Department of Biochemistry and Biophysics, University of California, San Francisco, CA, United States
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA
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Affiliation as printed
Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA
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Affiliation as printed
Geriatric Unit, Azienda Sanitaria Toscana Centro, Florence, Italy
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Amsterdam UMC Location University of Amsterdam · Amsterdam University Medical Centers · Amsterdam UMC Location Vrije Universiteit Amsterdam
Affiliation as printed
Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands
Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
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Leiden University Medical Center
Affiliation as printed
Department Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
Department Psychiatry, Leiden University Medical Center, Leiden, the Netherlands
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Maastricht University Medical Centre
Affiliation as printed
School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, Maastricht, The Netherlands
School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, Maastricht, the Netherlands
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Utrecht University · University Medical Center Utrecht · Ministry of Defence
Affiliation as printed
Brain Research & Innovation Centre, Ministry of Defence, Utrecht, the Netherlands
Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht University, The Netherlands
Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
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Utrecht University · University Medical Center Utrecht
Affiliation as printed
Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht University, The Netherlands
Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
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Utrecht University · University Medical Center Utrecht · GGNet
Affiliation as printed
Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht University, The Netherlands
Second Opinion Outpatient Clinic, GGNet Mental Health, Warnsveld, The Netherlands
Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
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Humboldt-Universität zu Berlin · Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Department of Psychiatry and Neurosciences, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Humboldt-Universität zu Berlin · Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Department of Psychiatry and Neurosciences, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Utrecht University · University Medical Center Utrecht · GGNet
Affiliation as printed
Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht University, The Netherlands
Second Opinion Outpatient Clinic, GGNet Mental Health, Warnsveld, The Netherlands
Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
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Columbia University Irving Medical Center · New York State Psychiatric Institute
Affiliation as printed
Departments of Psychiatry and Neurology, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, United States
New York State Psychiatric Institute, New York, NY United States
New York State Psychiatric Institute, New York, NY, USA
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Affiliation as printed
Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA
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University of Southern California
Affiliation as printed
Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA
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Utrecht University · University Medical Center Utrecht
Affiliation as printed
Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht University, The Netherlands
Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
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Affiliation as printed
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Elysium Health, Inc. (United States)
Affiliation as printed
Elysium Health, Inc, New York, NY, USA
Elysium Health, New York, NY, USA
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Morgan E. Levine corresponding
Affiliation as printed
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
San Diego Institute of Science, Altos Labs, San Diego, CA, USA
Cited by 460 stored of 489
Cited by patents worldwide 3 (Lens.org)
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METHODS FOR DETERMINING BIOLOGICAL AGE AND/OR BIOLOGICAL AGE GAPWO2026074209A1 2026-04-09 Pending
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METHODS OF DETERMINING BIOLOGICAL AGEWO2025010439A3 2025-04-03 Pending
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RETROELEMENT-AGE: BIOLOGICAL AGING CAPTURED BY LOCUS-SPECIFIC HUMAN ENDOGENOUS RETROVIRUSES AND LINE-1 DNA METHYLATION STATESWO2025043209A1 2025-02-27 Pending