Mapping Research Domain Criteria using a transdiagnostic mini-RDoC assessment in mental disorders: a confirmatory factor analysis
European Archives of Psychiatry and Clinical Neuroscience, vol. 273, pp. 527–539
Abstract
This study aimed to build on the relationship of well-established self-report and behavioral assessments to the latent constructs positive (PVS) and negative valence systems (NVS), cognitive systems (CS), and social processes (SP) of the Research Domain Criteria (RDoC) framework in a large transnosological population which cuts across DSM/ICD-10 disorder criteria categories. One thousand four hundred and thirty one participants (42.1% suffering from anxiety/fear-related, 18.2% from depressive, 7.9% from schizophrenia spectrum, 7.5% from bipolar, 3.4% from autism spectrum, 2.2% from other disorders, 18.4% healthy controls, and 0.2% with no diagnosis specified) recruited in studies within the German research network for mental disorders for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) were examined with a Mini-RDoC-Assessment including behavioral and self-report measures. The respective data was analyzed with confirmatory factor analysis (CFA) to delineate the underlying latent RDoC-structure. A revised four-factor model reflecting the core domains positive and negative valence systems as well as cognitive systems and social processes showed a good fit across this sample and showed significantly better fit compared to a one factor solution. The connections between the domains PVS, NVS and SP could be substantiated, indicating a universal latent structure spanning across known nosological entities. This study is the first to give an impression on the latent structure and intercorrelations between four core Research Domain Criteria in a transnosological sample. We emphasize the possibility of using already existing and well validated self-report and behavioral measurements to capture aspects of the latent structure informed by the RDoC matrix.
Authors 27
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Affiliation as printed
Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Am Neuen Palais 10, 14469, Potsdam, Germany
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Affiliation as printed
Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Am Neuen Palais 10, 14469, Potsdam, Germany
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Affiliation as printed
Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Am Neuen Palais 10, 14469, Potsdam, Germany
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Humboldt-Universität zu Berlin · Berlin Institute of Health at Charité - Universitätsmedizin Berlin · Freie Universität Berlin · Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Psychiatry and Psychotherapy CCM, Charité, Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
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Institut für Psychiatrische Phänomik und Genomik · Ludwig-Maximilians-Universität München
Affiliation as printed
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany
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Philipps University of Marburg
Affiliation as printed
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps University Marburg, Marburg, Germany
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Social Neuroscience Lab · University of Lübeck
Affiliation as printed
Social Neuroscience Lab, Department of Psychiatry and Psychotherapy, Center of Brain, Behavior, and Metabolism (CBBM), University of Lübeck, Lübeck, Germany
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Central Institute of Mental Health · Medizinische Fakultät Mannheim
Affiliation as printed
Department of Psychiatry and Psychotherapy, Mannheim, Central Institute of Mental Health, Medical Faculty Mannheim, Mannheim, Germany
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Central Institute of Mental Health · Medizinische Fakultät Mannheim
Affiliation as printed
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Mannheim, Germany
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University Hospital Carl Gustav Carus · Technische Universität Dresden
Affiliation as printed
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany
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Affiliation as printed
Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
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Max Planck Institute of Psychiatry
Affiliation as printed
Max Planck Institute of Psychiatry, Munich, Germany
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Technische Universität Dresden
Affiliation as printed
Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany
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Friedrich-Alexander-Universität Erlangen-Nürnberg · Technische Universität Dresden
Affiliation as printed
Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany
Translational Psychotherapy, Department of Psychology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
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Humboldt-Universität zu Berlin · Berlin Institute of Health at Charité - Universitätsmedizin Berlin · Freie Universität Berlin · Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Psychiatry and Psychotherapy CCM, Charité, Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
JARA-Brain, Research Center Jülich, Jülich, Germany
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Institut für Psychiatrische Phänomik und Genomik · Ludwig-Maximilians-Universität München
Affiliation as printed
Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany
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Frank W. Schneider Aachen Department of Psychiatry, Psychotherapy and Psychosomatics Faculty of Medicine
Düsseldorf University Hospital · Heinrich Heine University Düsseldorf · RWTH Aachen University
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
University Hospital Düsseldorf, Medical School, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
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Philipps University of Marburg
Affiliation as printed
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps University Marburg, Marburg, Germany
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Central Institute of Mental Health · Medizinische Fakultät Mannheim
Affiliation as printed
Department of Psychiatry and Psychotherapy, Mannheim, Central Institute of Mental Health, Medical Faculty Mannheim, Mannheim, Germany
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Ludwig-Maximilians-Universität München
Affiliation as printed
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
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Central Institute of Mental Health · Medizinische Fakultät Mannheim
Affiliation as printed
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Mannheim, Germany
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University Hospital Carl Gustav Carus · Technische Universität Dresden
Affiliation as printed
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany
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Affiliation as printed
Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
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Technische Universität Dresden · Ludwig-Maximilians-Universität München
Affiliation as printed
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany
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Michael A. Rapp corresponding
Affiliation as printed
Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Am Neuen Palais 10, 14469, Potsdam, Germany. michael.rapp@uni-potsdam.de
Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Am Neuen Palais 10, 14469, Potsdam, Germany
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