Cross‐Linkable Polyion Complex Micelles from Polypept(o)ide‐Based ABC‐Triblock Copolymers for siRNA Delivery

Macromolecular Rapid Communications, vol. 43

Abstract

Inside Cover: In article number 2100698 by Matthias Barz and co-workers, a reactive ABC-type triblock copolymer based on polypept(o)ide material, comprising a reactive polycysteine middle-block structure, enables the formation of cross-linkable polyion complex micelles to encapsulate siRNA. Beside the electrostatic interaction, cross-linking leads to highly increased stability. Purified polyion complex micelles further serve as an effective delivery system for siRNA in vitro. Attractive interactions to stabilize the polyion complex micelles are displayed by lightnings (red: electrostatic, yellow: cross-links). The combination of single components results in the formation of functional carrier systems (blue balls) to encapsulate siRNA (red) and deliver it into different cell types (picture from the publication, siRNA marked in red).

Authors 7

1. Leon Capelôa Aachen

   Leiden University · University of Vienna · Johannes Gutenberg University Mainz · Sichuan University · University Medical Center of the Johannes Gutenberg University Mainz · Ludwig-Maximilians-Universität München

   Affiliation as printed

   Leiden Academic Centre for Drug Research (LACDR) Leiden University Einstein weg 55 , Leiden 2333CC , The Netherlands

   Department of Dermatology University Medical Center Johannes Gutenberg-University Mainz Obere Zahlbacher Straße 63, 55131 Mainz, Germany

   Division of Pharmaceutical Technology and Biopharmaceutics University of Vienna Althanstrasse 14, Vienna 1090, Austria www.advancedsciencenews.com

   Leiden Academic Center for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   Leiden Academic Centre for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   National Engineering Research Center for Biomaterials

   Pharmaceutical Biotechnology Department of Pharmacy LMU Munich Butenandtstrasse 5-13, 81377 Munich, Germany

   Sichuan University Chengdu 610064, P. R. China U. Lächelt

2. Mina Yazdi Aachen

   Leiden University · University of Vienna · Johannes Gutenberg University Mainz · Sichuan University · University Medical Center of the Johannes Gutenberg University Mainz · Ludwig-Maximilians-Universität München

   Affiliation as printed

   Leiden Academic Centre for Drug Research (LACDR) Leiden University Einstein weg 55 , Leiden 2333CC , The Netherlands

   Department of Dermatology University Medical Center Johannes Gutenberg-University Mainz Obere Zahlbacher Straße 63, 55131 Mainz, Germany

   Division of Pharmaceutical Technology and Biopharmaceutics University of Vienna Althanstrasse 14, Vienna 1090, Austria www.advancedsciencenews.com

   Leiden Academic Center for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   National Engineering Research Center for Biomaterials

   Pharmaceutical Biotechnology Department of Pharmacy LMU Munich Butenandtstrasse 5-13, 81377 Munich, Germany

   Sichuan University Chengdu 610064, P. R. China U. Lächelt

3. Heyang Zhang Aachen

   Leiden University · University of Vienna · Johannes Gutenberg University Mainz · Sichuan University · University Medical Center of the Johannes Gutenberg University Mainz · Ludwig-Maximilians-Universität München

   Affiliation as printed

   Leiden Academic Centre for Drug Research (LACDR) Leiden University Einstein weg 55 , Leiden 2333CC , The Netherlands

   Department of Dermatology University Medical Center Johannes Gutenberg-University Mainz Obere Zahlbacher Straße 63, 55131 Mainz, Germany

   Division of Pharmaceutical Technology and Biopharmaceutics University of Vienna Althanstrasse 14, Vienna 1090, Austria www.advancedsciencenews.com

   Leiden Academic Center for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   Leiden Academic Centre for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   National Engineering Research Center for Biomaterials

   Pharmaceutical Biotechnology Department of Pharmacy LMU Munich Butenandtstrasse 5-13, 81377 Munich, Germany

   Sichuan University Chengdu 610064, P. R. China U. Lächelt

4. Xiaobing Chen Aachen

   Leiden University · University of Vienna · Johannes Gutenberg University Mainz · Sichuan University · University Medical Center of the Johannes Gutenberg University Mainz · Ludwig-Maximilians-Universität München

   Affiliation as printed

   Pharmaceutical Biotechnology Department of Pharmacy LMU Munich Butenandtstrasse 5-13 , 81377 Munich , Germany

   Department of Dermatology University Medical Center Johannes Gutenberg-University Mainz Obere Zahlbacher Straße 63, 55131 Mainz, Germany

   Division of Pharmaceutical Technology and Biopharmaceutics University of Vienna Althanstrasse 14, Vienna 1090, Austria www.advancedsciencenews.com

   Leiden Academic Center for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   Leiden Academic Centre for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   National Engineering Research Center for Biomaterials

   Pharmaceutical Biotechnology Department of Pharmacy LMU Munich Butenandtstrasse 5-13, 81377 Munich, Germany

   Sichuan University Chengdu 610064, P. R. China U. Lächelt

5. Ernst Wagner Aachen

   Leiden University · University of Vienna · Johannes Gutenberg University Mainz · Sichuan University · University Medical Center of the Johannes Gutenberg University Mainz · Ludwig-Maximilians-Universität München

   Affiliation as printed

   Pharmaceutical Biotechnology Department of Pharmacy LMU Munich Butenandtstrasse 5-13 , 81377 Munich , Germany

   Department of Dermatology University Medical Center Johannes Gutenberg-University Mainz Obere Zahlbacher Straße 63, 55131 Mainz, Germany

   Division of Pharmaceutical Technology and Biopharmaceutics University of Vienna Althanstrasse 14, Vienna 1090, Austria www.advancedsciencenews.com

   Leiden Academic Center for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   Leiden Academic Centre for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   National Engineering Research Center for Biomaterials

   Pharmaceutical Biotechnology Department of Pharmacy LMU Munich Butenandtstrasse 5-13, 81377 Munich, Germany

   Sichuan University Chengdu 610064, P. R. China U. Lächelt

6. Ulrich Lächelt Aachen

   Leiden University · University of Vienna · Johannes Gutenberg University Mainz · Sichuan University · University Medical Center of the Johannes Gutenberg University Mainz · Ludwig-Maximilians-Universität München

   Affiliation as printed

   Department of Dermatology University Medical Center Johannes Gutenberg-University Mainz Obere Zahlbacher Straße 63, 55131 Mainz, Germany

   Division of Pharmaceutical Technology and Biopharmaceutics University of Vienna Althanstrasse 14, Vienna 1090, Austria www.advancedsciencenews.com

   Leiden Academic Center for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   Leiden Academic Centre for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   National Engineering Research Center for Biomaterials

   Pharmaceutical Biotechnology Department of Pharmacy LMU Munich Butenandtstrasse 5-13, 81377 Munich, Germany

   Sichuan University Chengdu 610064, P. R. China U. Lächelt

7. Matthias Barz corresponding Aachen

   Leiden University · University of Vienna · Johannes Gutenberg University Mainz · Sichuan University · University Medical Center of the Johannes Gutenberg University Mainz · Ludwig-Maximilians-Universität München

   Affiliation as printed

   Leiden Academic Centre for Drug Research (LACDR) Leiden University Einstein weg 55 , Leiden 2333CC , The Netherlands

   U

   Department of Dermatology University Medical Center Johannes Gutenberg-University Mainz Obere Zahlbacher Straße 63, 55131 Mainz, Germany

   Division of Pharmaceutical Technology and Biopharmaceutics University of Vienna Althanstrasse 14, Vienna 1090, Austria www.advancedsciencenews.com

   Leiden Academic Center for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   Leiden Academic Centre for Drug Research (LACDR) Leiden University Einstein weg 55, Leiden 2333CC, The Netherlands

   National Engineering Research Center for Biomaterials

   Pharmaceutical Biotechnology Department of Pharmacy LMU Munich Butenandtstrasse 5-13, 81377 Munich, Germany

   Sichuan University Chengdu 610064, P. R. China U. Lächelt