Bisphosphonate therapy in chronic diffuse sclerosing osteomyelitis/tendoperiostitis of the mandible: Retrospective case series

Journal of Cranio-Maxillofacial Surgery, vol. 50, pp. 599–604

Abstract

This study aims to evaluate short-term and long-term results of bisphosphonate therapy in patients with diffuse sclerosing osteomyelitis/tendoperiostitis (DSO/TP) of the mandible. Eighteen patients (12 female, 6 male) aged 34.8 ± 22.2 years with DSO/TP of the mandible that were treated with bisphosphonates were included. In 16 patients, the bisphosphonate treatment led to remission with decrease of symptoms (pain, swelling of the cheek, trismus, tenderness of masticatory muscles) with a follow-up period of 4.5 (0.8-11.9) years between start of bisphosphonate treatment and latest follow-up consult. Of these, three patients were still in need of regular bisphosphonate therapy. Two patients were lost to follow-up. Bisphosphonate therapy is a treatment option for DSO/TP of the mandible that is associated with a high chance of remission of symptoms. Within the limitations of the study it seems that this treatment might be an effective second step in DSO/TP refractory to conservative treatment.

Authors 5

1. Marieke M. van de Meent Aachen Department of Oral & Maxillofacial Surgery (Chair: Prof. Dr. JPR van Merkesteyn)

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Oral and Maxillofacial Surgery, Leiden University Medical Centre, Leiden, the Netherlands

2. Natasha M. Appelman‐Dijkstra Aachen Center for Bone Quality Department of Internal Medicine Division of Endocrinology, Leiden University Medical Center

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Centre for Bone Quality, Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, the Netherlands

3. Miranda J.M. Wetselaar‐Glas Aachen Centre for Special Dental Care

   Leiden University Medical Center

   Affiliation as printed

   Centre for Special Dental Care, Leiden University Medical Center, Leiden, the Netherlands

4. Sarina E.C. Pichardo Aachen Department of Oral & Maxillofacial Surgery (Chair: Prof. Dr. JPR van Merkesteyn)

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Oral and Maxillofacial Surgery, Leiden University Medical Centre, Leiden, the Netherlands

5. J.P. Richard van Merkesteyn corresponding Aachen Department of Oral & Maxillofacial Surgery (Chair: Prof. Dr. JPR van Merkesteyn)

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Oral and Maxillofacial Surgery, Leiden University Medical Centre, Leiden, the Netherlands. Electronic address: J.P.R.van_Merkesteyn@lumc.nl

   Department of Oral and Maxillofacial Surgery, Leiden University Medical Centre, Leiden, the Netherlands