Additional cytogenetic features determine outcome in patients allografted for TP53 mutant acute myeloid leukemia
Cancer, vol. 128, pp. 2922–2931
Abstract
BACKGROUND: The presence of TP53 mutations is associated with an unfavorable outcome in patients allografted for acute myeloid leukemia (AML), leading some to question the benefit of an allogeneic stem cell transplantation (allo-SCT) for this patient group, although this has not been studied in a large cohort. METHODS: A total of 780 patients with AML in first complete remission, with either intermediate- or adverse-risk cytogenetics, whose TP53 mutation status was reported, were included in this study from the European Society for Blood and Marrow Transplantation. RESULTS: Two-year overall survival (OS) was impaired in patients (n = 179) with evidence of a TP53 mutation at diagnosis (35.1%; 95% confidence interval [CI], 26.7-43.7) as compared to the cohort without (n = 601) (64%; 95% CI, 59.1-68.4; P = .001). In patients with mutant TP53 AML with no evidence of either chromosome 17p loss (17p-) and/or complex karyotype (CK) (n = 53, 29.6%), 2-year OS was 65.2% (95% CI, 48.4-77.6). This was not significantly different to patients without TP53 mutations. In patients with mutant TP53 AML with either 17p- and/or CK (n = 126, 70.4%), the OS was lower (24.6%; 95% CI, 16.2-34; P = .001). CONCLUSIONS: In summary, the adverse prognostic effect of TP53 mutations in AML following an allo-SCT is not evident in patients with neither co-occurring 17p- and/or CK, and these data inform decisions regarding allo-SCT in patients with TP53 mutant AML.
Authors 18
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Queen Elizabeth Hospital Birmingham · Cancer Research UK Clinical Trials Unit · University of Birmingham
Affiliation as printed
Birmingham Center for Cellular Therapy and Transplantation Centre for Clinical Haematology, Queen Elizabeth Hospital Birmingham UK
Cancer Research UK, Clinical Trials Unit University of Birmingham Birmingham UK
Birmingham Center for Cellular Therapy and Transplantation, Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK
Cancer Research UK, Clinical Trials Unit, University of Birmingham, Birmingham, UK
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Inserm · Assistance Publique – Hôpitaux de Paris · Hôpital Saint-Antoine · Centre de Recherche Saint-Antoine · European Society for Blood and Marrow Transplantation · Université Pierre-et-Marie-Curie
Affiliation as printed
Acute Leukemia Working Party, Paris Study Office European Society for Blood and Marrow Transplantation Paris France
Haematology Department AP‐HP, Saint Antoine Hospital Paris France
INSERM, Centre de Recherche Saint‐Antoine (CRSA) Sorbonne Universités, UPMC Univ Paris 06 Paris France
Acute Leukemia Working Party, Paris Study Office, European Society for Blood and Marrow Transplantation, Paris, France
Haematology Department, AP-HP, Saint Antoine Hospital, Paris, France
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Queen Elizabeth Hospital Birmingham · Cancer Research UK Clinical Trials Unit · University of Birmingham
Affiliation as printed
Birmingham Center for Cellular Therapy and Transplantation Centre for Clinical Haematology, Queen Elizabeth Hospital Birmingham UK
Cancer Research UK, Clinical Trials Unit University of Birmingham Birmingham UK
Birmingham Center for Cellular Therapy and Transplantation, Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK
Cancer Research UK, Clinical Trials Unit, University of Birmingham, Birmingham, UK
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Erasmus MC · Erasmus MC Cancer Institute
Affiliation as printed
Department of Hematology, Erasmus MC Cancer Institute University Medical Center Rotterdam Rotterdam The Netherlands
Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Hospices Civils de Lyon · Hôpital Lyon Sud
Affiliation as printed
Hopital‐Lyon Sud, Hospices Civils de Lyon, Pierre Bénite France
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University Medical Center of the Johannes Gutenberg University Mainz
Affiliation as printed
Department of Hematology, Oncology, and Pneumology University Medical Center Mainz Mainz Germany
Department of Hematology, Oncology, and Pneumology, University Medical Center Mainz, Mainz, Germany
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Maastricht University Medical Centre
Affiliation as printed
Department Internal Medicine Hematology/Oncology University Hospital Maastricht Maastricht The Netherlands
Department Internal Medicine Hematology/Oncology, University Hospital Maastricht, Maastricht, The Netherlands
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Radboud University Nijmegen · Radboud University Medical Center
Affiliation as printed
Radboud University Medical Centre Nijmegen The Netherlands
Radboud University Medical Centre Nijmegen, The Netherlands
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University Medical Center Hamburg-Eppendorf
Affiliation as printed
University Hospital Eppendorf Bone Marrow Transplantation Centre Hamburg Germany
University Hospital Eppendorf, Bone Marrow Transplantation Centre, Hamburg, Germany
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Hospital Clínic de Barcelona · Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Affiliation as printed
Hospital Clinic, Department of Hematology IDIBAPS Barcelona Spain
Hospital Clinic, Department of Hematology, IDIBAPS, Barcelona, Spain
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Affiliation as printed
Centre Henri Becquerel, Hematology Rouen France
Centre Henri Becquerel, Hematology, Rouen, France
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Affiliation as printed
Department of Medicine Goethe University Frankfurt Frankfurt Main Germany
Department of Medicine, Goethe University Frankfurt, Frankfurt Main, Germany
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American University of Beirut Medical Center · American University of Beirut
Affiliation as printed
Bone Marrow Transplantation Program, Department of Internal Medicine American University of Beirut Medical Center Beirut Lebanon
Department of Anatomy, Cell Biology and Physiological Sciences American University of Beirut Beirut Lebanon
Bone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, Lebanon
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The Maria Sklodowska-Curie National Research Institute of Oncology
Affiliation as printed
Maria Sklodowsk‐Curie Memorial Cancer Centre and Institute of Oncology Gliwice Poland
Maria Sklodowsk-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice, Poland
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Inserm · Assistance Publique – Hôpitaux de Paris · Hôpital Saint-Antoine · Centre de Recherche Saint-Antoine · Université Pierre-et-Marie-Curie
Affiliation as printed
Haematology Department AP‐HP, Saint Antoine Hospital Paris France
INSERM, Centre de Recherche Saint‐Antoine (CRSA) Sorbonne Universités, UPMC Univ Paris 06 Paris France
Haematology Department, AP-HP, Saint Antoine Hospital, Paris, France
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Affiliation as printed
Hematology Division, Chaim Sheba Medical Center, Tel Hashomer Ramat Gan Israel
Hematology Division, Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel
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Hospital Clínic de Barcelona · Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Affiliation as printed
Hospital Clinic, Department of Hematology IDIBAPS Barcelona Spain
Hospital Clinic, Department of Hematology, IDIBAPS, Barcelona, Spain
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Mohamad Mohty corresponding
Inserm · Assistance Publique – Hôpitaux de Paris · Hôpital Saint-Antoine · Centre de Recherche Saint-Antoine · Université Pierre-et-Marie-Curie
Affiliation as printed
Haematology Department AP‐HP, Saint Antoine Hospital Paris France
INSERM, Centre de Recherche Saint‐Antoine (CRSA) Sorbonne Universités, UPMC Univ Paris 06 Paris France
Haematology Department, AP-HP, Saint Antoine Hospital, Paris, France
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