Author response: Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

Abstract

The transcriptomes of hematopoietic stem and progenitor cells of human juvenile myelomonocytic leukemia patients and a zebrafish model for Noonan syndrome reveal a common inflammatory response, which may have a causal role in associated myeloproliferative neoplasm.

Authors 12

1. Maja Šolman

   University Medical Center Utrecht · Hubrecht Institute for Developmental Biology and Stem Cell Research

   Affiliation as printed

   Hubrecht Institute-KNAW and UMC Utrecht

2. Sasja Blokzijl-Franke

   University Medical Center Utrecht · Hubrecht Institute for Developmental Biology and Stem Cell Research

   Affiliation as printed

   Hubrecht Institute-KNAW and UMC Utrecht

3. Florian Piques

   Inserm · Université Paris Cité · Assistance Publique – Hôpitaux de Paris · Hôpital Robert-Debré · Institut de recherche Saint-Louis · Hématopoïèse normale et pathologique : Emergence, environnement et recherche translationnelle

   Affiliation as printed

   Assistance Publique des Hôpitaux de Paris AP-HP, Hôpital Robert Debré, Département de Génétique

   INSERM UMR_S1131, Institut de Recherche Saint-Louis, Université de Paris

4. Chuan Yan

   Massachusetts General Hospital · Harvard Stem Cell Institute

   Affiliation as printed

   Center for Regenerative Medicine, Massachusetts General Hospital

   Harvard Stem Cell Institute

   Massachusetts General Hospital Cancer Center

   Molecular Pathology Unit, Massachusetts General Hospital Research Institute

5. Qiqi Yang

   Massachusetts General Hospital · Harvard Stem Cell Institute

   Affiliation as printed

   Center for Regenerative Medicine, Massachusetts General Hospital

   Harvard Stem Cell Institute

   Massachusetts General Hospital Cancer Center

   Molecular Pathology Unit, Massachusetts General Hospital Research Institute

6. Marion Strullu

   Inserm · Université Paris Cité · Assistance Publique – Hôpitaux de Paris · Hôpital Robert-Debré · Institut de recherche Saint-Louis · Hématopoïèse normale et pathologique : Emergence, environnement et recherche translationnelle · Laboratoire d'hématologie

   Affiliation as printed

   Assistance Publique des Hôpitaux de Paris AP-HP, Hôpital Robert Debré, Service d’Onco-Hématologie Pédiatrique

   INSERM UMR_S1131, Institut de Recherche Saint-Louis, Université de Paris

7. Sarah M. Kamel

   University Medical Center Utrecht · Hubrecht Institute for Developmental Biology and Stem Cell Research

   Affiliation as printed

   Hubrecht Institute-KNAW and UMC Utrecht

8. Pakize Ak

   University Medical Center Utrecht · Hubrecht Institute for Developmental Biology and Stem Cell Research

   Affiliation as printed

   Hubrecht Institute-KNAW and UMC Utrecht

9. Jeroen Bakkers

   University Medical Center Utrecht · Hubrecht Institute for Developmental Biology and Stem Cell Research

   Affiliation as printed

   Department of Medical Physiology, Division of Heart and Lungs, UMC Utrecht

   Hubrecht Institute-KNAW and UMC Utrecht

10. David M. Langenau

    Massachusetts General Hospital · Harvard Stem Cell Institute

    Affiliation as printed

    Center for Regenerative Medicine, Massachusetts General Hospital

    Harvard Stem Cell Institute

    Massachusetts General Hospital Cancer Center

    Molecular Pathology Unit, Massachusetts General Hospital Research Institute

11. Hélène Cavé

    Inserm · Université Paris Cité · Assistance Publique – Hôpitaux de Paris · Hôpital Robert-Debré · Institut de recherche Saint-Louis · Hématopoïèse normale et pathologique : Emergence, environnement et recherche translationnelle

    Affiliation as printed

    Assistance Publique des Hôpitaux de Paris AP-HP, Hôpital Robert Debré, Département de Génétique

    INSERM UMR_S1131, Institut de Recherche Saint-Louis, Université de Paris

12. Jeroen den Hertog Aachen Institute of Biology Leiden

    Leiden University · University Medical Center Utrecht · Hubrecht Institute for Developmental Biology and Stem Cell Research

    Affiliation as printed

    Hubrecht Institute-KNAW and UMC Utrecht

    Institute of Biology Leiden, Leiden University