Robotic surgery using a DROP-IN beta probe – feasibility study with 68Ga-PSMA in prostate cancer specimens
Abstract
Abstract Background: Recently, a flexible DROP-IN gamma-probe was introduced for robot-assisted radioguided surgery, using traditional low-energy SPECT-isotopes. This study explores the use of a novel DROP-IN beta-particle (DROP-IN b ) detection probe to support the implementation of the large number of PET-tracers available during robot-assisted tumor-receptor-targeted resections. Methods: Following engineering of the DROP-IN b probe, robotic implementation was investigated using surgical specimens. Seven prostate cancer patients with PSMA-PET positive tumors received an intraoperative injection of ~100 MBq 68 Ga-PSMA-11, followed by prostatectomy and extended pelvic lymph node dissection. Results: The probe was able to identify the position of the tumor in the prostate specimens: S/B was > 5 when pathology confirmed that the tumor was located <1 mm below the specimen surface. PSMA-PET positive lymph nodes, as found in two patients, could be identified with the DROP-IN b probe (S/B>3). Conclusions: This ex vivo study underlines the potential to use a DROP-IN b probe for intraoperative tumor identification on the prostate surface and confirmation of PSMA-PET positive lymph nodes.
Authors 16
-
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
Affiliation as printed
Istituto Nazionale di Fisica Nucleare Sezione di Roma
-
Matthias van Oosterom Aachen Interventional Molecular Imaging Laboratory Department of Radiology, Leiden University Medical Center
Leiden University Medical Center
Affiliation as printed
Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden university Medical Center
-
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
Affiliation as printed
Istituto Nazionale di Fisica Nucleare Sezione di Roma
-
Affiliation as printed
Universita degli Studi di Roma La Sapienza Dipartimento di Fisica
-
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
Affiliation as printed
Istituto Nazionale di Fisica Nucleare Sezione di Roma
-
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
Affiliation as printed
Istituto Nazionale di Fisica Nucleare Sezione di Roma
-
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
Affiliation as printed
Istituto Nazionale di Fisica Nucleare Sezione di Roma
-
Università Cattolica del Sacro Cuore
Affiliation as printed
Scuola di specializzazione in fisica medica, Università Cattolica del Sacro Cuore, Roma
-
The Netherlands Cancer Institute
Affiliation as printed
Department of Nuclear Medicine, Antoni van Leeuwenhoek Nederlands Kanker Instituut
-
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
Affiliation as printed
Istituto Nazionale di Fisica Nucleare Sezione di Roma
-
Florian van Beurden Aachen Interventional Molecular Imaging Laboratory Department of Radiology, Leiden Univeristy Medical center
Leiden University · Leiden University Medical Center
Affiliation as printed
Interventional molecular imaging laboratory, Department of Radiology, Leiden Univeristy Medical center, Leiden
-
The Netherlands Cancer Institute
Affiliation as printed
Department of Urology, Antoni van Leeuwenhoek Nederlands Kanker Instituut
-
Leiden University Medical Center
Affiliation as printed
Interventional Molecular Imaging Laboratory, Leiden university medical center, Leiden
-
The Netherlands Cancer Institute
Affiliation as printed
Department of Urology, Antoni van Leeuwenhoek Nederlands Kanker Instituut
-
The Netherlands Cancer Institute
Affiliation as printed
Department of urology, Antoni van Leeuwenhoek Nederlands Kanker Instituut
-
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
Affiliation as printed
Istituto Nazionale di Fisica Nucleare Sezione di Roma
Cited by 1 stored of 1
1 result
No patents citing this paper on Lens.org (checked 2026-10-11).