Author response: A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast

Abstract

In mitotically aging yeast cells, the cytosol acidifies, the distances between the organellar membranes decrease dramatically, but crowding on the scale of the average size protein is relatively stable.

Authors 10

1. Sara N. Mouton

   University Medical Center Groningen · University of Groningen

   Affiliation as printed

   European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen

2. David J. Thaller

   Yale University

   Affiliation as printed

   Department of Cell Biology, Yale School of Medicine

3. Matthew M. Crane

   University of Washington

   Affiliation as printed

   Department of Pathology, School of Medicine, University of Washington

4. Irina L. Rempel

   University Medical Center Groningen · University of Groningen

   Affiliation as printed

   European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen

5. Owen T Terpstra

   University Medical Center Groningen · University of Groningen

   Affiliation as printed

   European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen

6. Anton Steen

   University Medical Center Groningen · University of Groningen

   Affiliation as printed

   European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen

7. Matt R. Kaeberlein

   University of Washington

   Affiliation as printed

   Department of Pathology, School of Medicine, University of Washington

8. C. Patrick Lusk

   Yale University

   Affiliation as printed

   Department of Cell Biology, Yale School of Medicine

9. Arnold J. Boersma Aachen DWI - Leibniz Institute for Interactive Materials

   DWI – Leibniz Institute for Interactive Materials

   Affiliation as printed

   DWI-Leibniz Institute for Interactive Materials

10. Liesbeth M. Veenhoff

    University Medical Center Groningen · University of Groningen

    Affiliation as printed

    European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen