Safe and efficient 2D molybdenum disulfide platform for cooperative imaging-guided photothermal-selective chemotherapy: A preclinical study
Journal of Advanced Research, vol. 37, pp. 255–266
Abstract
The striking imbalance between the ever-increasing amount of nanomedicines and low clinical translation of products has become the focus of intense debate. For clinical translation, the critical issue is to select the appropriate agents and combination regimen for targeted diseases, not to prepare increasingly complex nanoplatforms. A safe and efficient platform, α-tocopheryl succinate (α-TOS) married 2D molybdenum disulfide, was devised by a facile method and applied for cooperative imaging-guided photothermal-selective chemotherapy of ovarian carcinoma. A novel platform of PEGylated α-TOS and folic acid (FA) conjugated 2D MoS2 nanoflakes was fabricated for the cooperative multimode computed tomography (CT)/photoacoustic (PA)/thermal imaging-guided photothermal-selective chemotherapy of ovarian carcinoma. The photothermal efficiency (65.3%) of the platform under safe near-infrared irradiation is much higher than that of other photothermal materials reported elsewhere. Moreover, the covalently linked α-TOS renders platform with selective chemotherapy for cancer cells. Remarkably, with these excellent properties, the platform can be used to completely eliminate the solid tumor by safe photothermal therapy, and then kill the residual cancer cells by selective chemotherapy to prevent tumor recurrence. More significantly, barely side effects occur in the whole treatment process. The excellent efficacy and safety benefits in vivo lead to the prominent survival rate of 100% over 91 days. The safe and efficient platform might be a candidate of clinical nanomedicines for multimode theranostics. This study demonstrates an innovative thought in precise nanomedicine regarding the design of next generation of cancer theranostic protocol for potential clinical practice.
Authors 8
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Xin Li Aachen DWI-Leibniz-Institute for Interactive Materials e.V Institute of Technical and Macromolecular Chemistry
Shanghai Jiao Tong University · XinHua Hospital · DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University
Affiliation as printed
DWI-Leibniz-Institute for Interactive Materials e.V., 52056 Aachen, Germany
Department of Gynecology and Obstetrics, XinHua Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai 200092, China
Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, 52074 Aachen, Germany
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Affiliation as printed
Laboratory of Nanoscale Biosensing and Bioimaging, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China
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Affiliation as printed
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
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Affiliation as printed
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
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Andrij Pich Aachen DWI-Leibniz-Institute for Interactive Materials e.V Institute of Technical and Macromolecular Chemistry
Maastricht University · DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University
Affiliation as printed
Aachen Maastricht Institute for Biobased Materials, Maastricht University, 6167 RD Geleen, the Netherlands
DWI-Leibniz-Institute for Interactive Materials e.V., 52056 Aachen, Germany
Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, 52074 Aachen, Germany
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Xiangyang Shi corresponding
Donghua University · Centro de Química da Madeira · Universidade da Madeira
Affiliation as printed
CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
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Xipeng Wang corresponding
Shanghai Jiao Tong University · XinHua Hospital
Affiliation as printed
Department of Gynecology and Obstetrics, XinHua Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai 200092, China
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Lingxi Xing corresponding
Shanghai Jiao Tong University · XinHua Hospital
Affiliation as printed
Department of Gynecology and Obstetrics, XinHua Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai 200092, China
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