Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle

Membranes, vol. 12, pp. 56

Abstract

Carbon monoxide (CO) poisoning is the leading cause of poisoning-related deaths globally. The currently available therapy options are normobaric oxygen (NBO) and hyperbaric oxygen (HBO). While NBO lacks in efficacy, HBO is not available in all areas and countries. We present a novel method, extracorporeal hyperoxygenation therapy (EHT), for the treatment of CO poisoning that eliminates the CO by treating blood extracorporeally at elevated oxygen partial pressure. In this study, we proof the principle of the method in vitro using procine blood: Firstly, we investigated the difference in the CO elimination of a hollow fibre membrane oxygenator and a specifically designed batch oxygenator based on the bubble oxygenator principle at elevated pressures (1, 3 bar). Secondly, the batch oxygenator was redesigned and tested for a broader range of pressures (1, 3, 5, 7 bar) and temperatures (23, 30, 37 °C). So far, the shortest measured carboxyhemoglobin half-life in the blood was 21.32 min. In conclusion, EHT has the potential to provide an easily available and effective method for the treatment of CO poisoning.

Authors 9

1. Niklas B. Steuer corresponding Aachen Medical Faculty Institute of Applied Medical Engineering Department of Cardiovascular Engineering

   RWTH Aachen University

   Affiliation as printed

   Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany

2. Peter Schlanstein Aachen Medical Faculty Institute of Applied Medical Engineering Department of Cardiovascular Engineering

   RWTH Aachen University

   Affiliation as printed

   Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany

3. Anke Hannig Aachen Medical Faculty Institute of Applied Medical Engineering Department of Cardiovascular Engineering

   RWTH Aachen University

   Affiliation as printed

   Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany

4. Stephan Sibirtsev Aachen Fluid Process Engineering (AVT.FVT)

   RWTH Aachen University

   Affiliation as printed

   Fluid Process Engineering (AVT.FVT), RWTH Aachen University, Forckenbeckstraße 51, 52074 Aachen, Germany

5. Andreas Jupke Aachen Fluid Process Engineering (AVT.FVT)

   RWTH Aachen University

   Affiliation as printed

   Fluid Process Engineering (AVT.FVT), RWTH Aachen University, Forckenbeckstraße 51, 52074 Aachen, Germany

6. Thomas Schmitz‐Rode Aachen Medical Faculty Institute of Applied Medical Engineering

   RWTH Aachen University

   Affiliation as printed

   Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany

7. Rüdger Kopp Aachen Medical Faculty Department of Intensive Care Medicine

   RWTH Aachen University

   Affiliation as printed

   Department of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany

8. Ulrich Steinseifer Aachen Medical Faculty Institute of Applied Medical Engineering Department of Cardiovascular Engineering

   RWTH Aachen University

   Affiliation as printed

   Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany

9. Jutta Arens Aachen Medical Faculty Institute of Applied Medical Engineering Department of Cardiovascular Engineering

   RWTH Aachen University · University of Twente

   Affiliation as printed

   Department of Biomechanical Engineering, Faculty of Engineering Technology, University of Twente, De Horst 2, 7522LW Enschede, The Netherlands

   Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany