Parameter optimization and validation of a cost efficient hybrid mock loop of the cardiovascular system

European Control Conference (ECC), pp. 762–768

Abstract

This paper presents a nonlinear parameter optimization of closed-circuit cardiovascular models. We use animal trial data to fit the cardiovascular model and find optimized parameters. The model is programmed in Modelica, and we use JModelica for the optimization. We introduce a cost-efficient hardware in the loop test bench to design and evaluate controllers for left ventricular assist devices. The optimization results show that the chosen modeling approach is well suited to reflect the animal’s physiological behavior in the chosen operating point. The results of an in vitro experiment prove that the cost-efficient hybrid mock loop is capable of creating the pressure boundaries for left ventricular assist devices.

Authors 6

1. Tobias Salesch Aachen Institute of Automatic Control (IRT)

   RWTH Aachen University

   Affiliation as printed

   Institute of Automatic Control, RWTH Aachen University, Aachen, Germany

2. Jonas Gesenhues Aachen Institute of Automatic Control (IRT)

   RWTH Aachen University

   Affiliation as printed

   Institute of Automatic Control, RWTH Aachen University, Aachen, Germany

3. Moriz Habigt Aachen

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   RWTH Aachen University Hospital, Aachen, Germany

4. Mare Mechelinck Aachen

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   RWTH Aachen University Hospital, Aachen, Germany

5. Marc Hein Aachen

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   RWTH Aachen University Hospital, Aachen, Germany

6. Dirk Abel Aachen Institute of Automatic Control (IRT)

   RWTH Aachen University

   Affiliation as printed

   Institute of Automatic Control, RWTH Aachen University, Aachen, Germany