Spike pattern detection and evaluation in epileptogenic human brain tissue – on the hunt for micro-circuit network anomalies

Brain and Spine, vol. 1, pp. 100708

Abstract

Results: Our sample follows a normal distribution for f0, jitter, shimmer and HNR.Pearson r test revealed a correlation between pre-op f0 and post-op at target.Paired t-tests revealed that there was no statistical significance pre-op and post-op.One sample t-test showed a statistically significant difference for the post-operative shimmer.Conclusion: Our results from six patients support the fact that the unilateral placement and the activation of an electrode in the posterior subthalamic area do not have an effect on the patient's voice.

Authors 10

1. Jonas Ort Aachen Department of Neurosurgery Neurosurgical Artificial Intelligence Lab Aachen (NAILA)

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Neurosurgery, RWTH Aachen University, Medical Faculty, Aachen, Germany

   Neurosurgical Artificial Intelligence Lab Aachen (NAILA), RWTH Aachen University Hospital, Aachen, Germany

2. Jenny Wickham

   Natural and Medical Sciences Institute · University of Tübingen

   Affiliation as printed

   Neurophysics, Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany

3. Aniella Bak Aachen Department of Epileptology, Neurology

   RWTH Aachen University

   Affiliation as printed

   Department of Epileptology, Neurology, RWTH Aachen University, Medical Faculty, Aachen, Germany

4. Andrea Corna

   Natural and Medical Sciences Institute · University of Tübingen

   Affiliation as printed

   Neurophysics, Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany

5. Thomas V. Wuttke

   Hertie Institute for Clinical Brain Research · University of Tübingen

   Affiliation as printed

   Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

   Department of Neurosurgery, University of Tübingen, Tübingen, Germany

6. Hans Clusmann Aachen Department of Neurosurgery

   RWTH Aachen University

   Affiliation as printed

   Department of Neurosurgery, RWTH Aachen University, Medical Faculty, Aachen, Germany

7. Yvonne G. Weber Aachen Department of Epileptology, Neurology

   RWTH Aachen University

   Affiliation as printed

   Department of Epileptology, Neurology, RWTH Aachen University, Medical Faculty, Aachen, Germany

8. Günther M. Zeck

   TU Wien

   Affiliation as printed

   Institute of Electrodynamics, Microwave and Circuit Engineering, Vienna University of Technology, Vienna, Austria

9. Daniel Delev Aachen Department of Neurosurgery Neurosurgical Artificial Intelligence Lab Aachen (NAILA)

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Neurosurgery, RWTH Aachen University, Medical Faculty, Aachen, Germany

   Neurosurgical Artificial Intelligence Lab Aachen (NAILA), RWTH Aachen University Hospital, Aachen, Germany

10. Henner Koch Aachen Department of Epileptology, Neurology

    RWTH Aachen University

    Affiliation as printed

    Department of Epileptology, Neurology, RWTH Aachen University, Medical Faculty, Aachen, Germany