Retrospective observational study evaluating zinc plasma level in patients undergoing thoracoabdominal aortic aneurysm repair and its correlation with outcome

Scientific Reports, vol. 11, pp. 24348

Abstract

Thoracoabdominal aortic aneurysm (TAAA) repair is related to a relevant morbidity and in-hospital mortality rate. In this retrospective observational single-center study including serum zinc levels of 33 patients we investigated the relationship between zinc and patients' outcome following TAAA repair. Six patients died during the hospital stay (18%). These patients showed significantly decreased zinc levels before the intervention (zinc levels before intervention: 60.09 µg/dl [survivors] vs. 45.92 µg/dl [non-survivors]). The post-interventional intensive care SOFA-score (Sepsis-related organ failure assessment) (at day 2) as well as the SAPS (Simplified Acute Physiology Score) (at day 2) showed higher score points in case of low pre-interventional zinc levels. No significant correlation between patient comorbidities and zinc level before intervention, except for peripheral arterial disease (PAD), which was significantly correlated to reduced baseline zinc levels, was observed. Septic shock, pneumonia and urinary tract infections were not associated to reduced zinc levels preoperatively as well as during therapy. Patients with adverse outcome after TAAA repair showed reduced pre-interventional zinc levels. We speculate that decreased zinc levels before intervention may be related to a poorer outcome because of poorer physical status as well as negatively altered perioperative inflammatory response.

Authors 8

1. Benjamin Rolles Aachen Department of Hematology, Oncology Faculty of Medicine Institute of Immunology

   RWTH Aachen University

   Affiliation as printed

   Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf (CIO ABCD), Cologne, Germany

   Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany

   Institute of Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany

2. Inga Weßels Aachen Institute of Immunology Faculty of Medicine

   RWTH Aachen University

   Affiliation as printed

   Institute of Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany

3. Drosos Kotelis Aachen Department of Vascular Surgery

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Vascular Surgery, European Vascular Center Aachen-Maastricht, University Hospital RWTH Aachen, Aachen, Germany

4. Lothar Rink Aachen Institute of Immunology Faculty of Medicine

   RWTH Aachen University

   Affiliation as printed

   Institute of Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany

5. Margherita Vieri Aachen Department of Hematology, Oncology Faculty of Medicine

   RWTH Aachen University

   Affiliation as printed

   Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf (CIO ABCD), Cologne, Germany

   Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany

6. Fabian Beier Aachen Department of Hematology, Oncology Faculty of Medicine

   RWTH Aachen University

   Affiliation as printed

   Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf (CIO ABCD), Cologne, Germany

   Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany

7. Michael Johan Jacobs Aachen Department of Vascular Surgery

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Vascular Surgery, European Vascular Center Aachen-Maastricht, University Hospital RWTH Aachen, Aachen, Germany

8. Alexander Gombert corresponding Aachen Department of Vascular Surgery

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Vascular Surgery, European Vascular Center Aachen-Maastricht, University Hospital RWTH Aachen, Aachen, Germany. agombert@ukaachen.de

   Department of Vascular Surgery, European Vascular Center Aachen-Maastricht, University Hospital RWTH Aachen, Aachen, Germany