Selective Approaches to α‐ and β‐Arylated Vinyl Ethers

Angewandte Chemie, vol. 134

Abstract

Abstract We developed simple and efficient protocols for palladium‐catalyzed regioselective α‐ and β‐arylations of structurally diverse vinyl ethers. Both catalytic methods proceed under relatively mild reactions conditions applying to a broad substrate range including more complex compounds providing arylated glucal or isochromene. Lacking the common requirement of a large reagent excess, the transformations are highly economic and limiting the waste production. Results from computational studies (DFT) provided insight into the key factors determining the pronounced regioselectivities of the investigated reactions.

Authors 4

1. Anna Domżalska Aachen Institut für Organische Chemie

   RWTH Aachen University

   Affiliation as printed

   Institut für Organische Chemie RWTH Aachen University Landoltweg 1 52074 Aachen Germany

2. Ignacio Funes‐Ardoiz

   Universidad de La Rioja

   Affiliation as printed

   Departamento de Química Centro de Investigación en Síntesis Química (CISQ) University of La Rioja Madre de Dios 53 26006 Logroño Spain

3. Bartłomiej Furman

   Institute of Organic Chemistry · Polish Academy of Sciences

   Affiliation as printed

   Institute of Organic Chemistry Polish Academy of Sciences Kasprzaka 44/52 01-224 Warsaw Poland

   Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland

4. Carsten Bolm corresponding Aachen Institut für Organische Chemie

   RWTH Aachen University

   Affiliation as printed

   Institut für Organische Chemie RWTH Aachen University Landoltweg 1 52074 Aachen Germany