Human engineered heart tissue as a model system for drug testing

• Proteome modulation by opposite inotropic drugs in human engineered cardiac tissue revealed by topology-driven cross-modal integration

  2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Chemistry Advanced Proteomics Techniques and Applications Open access

  0

  citations
• YAP1 reactivation in cardiomyocytes following ECM remodelling contributes to the development of contractile force and sarcomere maturation

  2025 Cell Death Discovery article Biochemistry, Genetics and Molecular Biology Hippo pathway signaling and YAP/TAZ Open access

  1

  citations
• YAP1 Contributes to The Development of Contractile Force and Sarcomere Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes

  2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Congenital heart defects research Open access

  1

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• Miniaturized engineered heart tissues from hiPSC-derived triple cell type co-cultures to study human cardiac function

  2023 Biochemical and Biophysical Research Communications article Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access cited by 1 patent

  17

  citations
• Automated assessment of human engineered heart tissues using deep learning and template matching for segmentation and tracking

  2023 Bioengineering & Translational Medicine article Biochemistry, Genetics and Molecular Biology Cell Image Analysis Techniques Open access

  8

  citations
• A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues

  2022 Journal of Personalized Medicine article Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access

  21

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• Development of a 3-Dimensional Model to Study Right Heart Dysfunction in Pulmonary Arterial Hypertension: First Observations

  2021 Cells article Medicine Pulmonary Hypertension Research and Treatments Open access

  9

  citations
• Cardiac Tissues From Stem Cells

  2021 Circulation Research article Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access

  96

  citations
• Engineered models of the human heart: Directions and challenges

  2020 Stem Cell Reports article Engineering 3D Printing in Biomedical Research Open access

  53

  citations
• A Miniaturized EHT Platform for Accurate Measurements of Tissue Contractile Properties

  2020 Journal of Microelectromechanical Systems article Biochemistry, Genetics and Molecular Biology Cellular Mechanics and Interactions Open access cited by 9 patents

  42

  citations
• Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes

  2020 Toxicological Sciences article Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access

  74

  citations

11 results