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A Novel In Vitro Membrane Permeability Methodology Using Three-dimensional Caco-2 Tubules in a Microphysiological System Which Better Mimics In Vivo Physiological Conditions

Journal of Pharmaceutical Sciences, vol. 111, pp. 214–224

Authors 10

  1. Astellas Pharma (Japan)

    Affiliation as printed

    Analytical Research Laboratories, Astellas Pharma Inc., Yaizu, Shizuoka 425-0072, Japan

  2. Astellas Pharma (Netherlands)

    Affiliation as printed

    European Analytical Research Laboratories, Astellas Pharma Europe B.V., Leiden 2333 BE, the Netherlands

  3. Mimetas (Netherlands)

    Affiliation as printed

    Mimetas B.V., Oegstgeest 2342 DH, the Netherlands

  4. Mimetas (Netherlands)

    Affiliation as printed

    Mimetas B.V., Oegstgeest 2342 DH, the Netherlands

  5. Mimetas (Netherlands)

    Affiliation as printed

    Mimetas B.V., Oegstgeest 2342 DH, the Netherlands

  6. Mimetas (Netherlands)

    Affiliation as printed

    Mimetas B.V., Oegstgeest 2342 DH, the Netherlands

  7. Shizuoka University · University of Shizuoka

    Affiliation as printed

    Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan

  8. Astellas Pharma (Japan)

    Affiliation as printed

    Analytical Research Laboratories, Astellas Pharma Inc., Yaizu, Shizuoka 425-0072, Japan

  9. Astellas Pharma (Japan)

    Affiliation as printed

    Analytical Research Laboratories, Astellas Pharma Inc., Yaizu, Shizuoka 425-0072, Japan

  10. Tomokazu Tajiri corresponding

    Astellas Pharma (Japan)

    Affiliation as printed

    Pharmaceutical Science and Technology Laboratories, Astellas Pharma Inc., Tsukuba, Ibaraki 300-2698, Japan. Electronic address: tomokazu.tajiri@astellas.com

    Pharmaceutical Science and Technology Laboratories, Astellas Pharma Inc., Tsukuba, Ibaraki 300-2698, Japan

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References 60