Heart function assessment during aging in apolipoprotein E knock-out mice
Discoveries, vol. 9, pp. e136
Abstract
BACKGROUND: Apolipoprotein (apo) E isoforms have strong correlations with metabolic and cardiovascular diseases. However, it is not clear if apoE has a role in development of non-ischemic cardiomyopathy. Our study aims to analyze the involvement of apoE in non-ischemic cardiomyopathy. METHODS AND RESULTS: Serial echo-cardiographic measurements were performed in old wildtype and apoE deficient (apoE-/-) mice. Morphological and functional cardiac parameters were in normal range in both groups at the age of 12 month. At the age of 18 months, both groups had shown ventricular dilation and increased heart rates. However, the apoE-/- mice presented signs of diastolic dysfunction by hypertrophic changes in left ventricle, due probably to arterial hypertension. The right ventricle was not affected by age or genotype. CONCLUSION: Even in the absence of high fat diet, apoE deficiency in mice induces mild changes in the cardiac function of the left ventricle during aging, by developing diastolic dysfunction, which leads to heart failure with preserved ejection fraction. However, further studies are necessary to conclude over the role of apoE in cardiac physiology and its involvement in development of heart failure.
Authors 6
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University of Medicine and Pharmacy of Craiova · Institutul National Victor Babes · Universitätsklinikum Aachen
Affiliation as printed
Department of Cardiology, Angiology and Intensive Care, Medical Faculty, University Hospital Aachen, Aachen, Germany
Human Genetic Laboratory, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Victor Babes National Institute of Pathology, Bucharest, Romania
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Affiliation as printed
Nicolae Simionescu Institute of Cellular Biology and Pathology, Bucharest, Romania
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University of Medicine and Pharmacy of Craiova · Universitätsklinikum Aachen
Affiliation as printed
Department of Cardiology, Angiology and Intensive Care, Medical Faculty, University Hospital Aachen, Aachen, Germany
Human Genetic Laboratory, University of Medicine and Pharmacy of Craiova, Craiova, Romania
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University of Medicine and Pharmacy of Craiova
Affiliation as printed
Human Genetic Laboratory, University of Medicine and Pharmacy of Craiova, Craiova, Romania
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Institutul National Victor Babes
Affiliation as printed
Victor Babes National Institute of Pathology, Bucharest, Romania
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Affiliation as printed
Nicolae Simionescu Institute of Cellular Biology and Pathology, Bucharest, Romania
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