A randomized clinical study using optical coherence tomography to evaluate the short‐term effects of high‐intensity interval training on cardiac allograft vasculopathy: a HITTS substudy
Clinical Transplantation, vol. 36, pp. e14488
Abstract
Abstract Cardiac allograft vasculopathy (CAV) remains a leading cause of long‐term mortality after heart transplantation. Both preventive measures and treatment options are limited. This study aimed to evaluate the short‐term effects of high‐intensity interval training (HIT) on CAV in de novo heart transplant (HTx) recipients as assessed by optical coherence tomography (OCT). The study population was a subgroup of the 81‐patient HITTS study in which HTx recipients were randomized to HIT or moderate intensity continuous training (MICT) for nine consecutive months. OCT images from baseline and 12 months were compared to assess CAV progression. The primary endpoint was defined as the change in the mean intima area. Paired OCT data were available for 56 patients (n = 23 in the HIT group and n = 33 in the MICT group). The intima area in the entire study population increased by 25% [from 1.8±1.4 mm2 to 2.3±2.0 mm2, P < .05]. The change was twofold higher in the MICT group (.6±1.2 mm2) than in the HIT group (.3±.6 mm2). However, the treatment effect of HIT was not significant (treatment effect = –.3 mm2, 95% CI [–.825 to .2 mm2] P = .29). These results suggest that early initiation of HIT compared with MICT does not attenuate CAV progression in de novo HTx recipients.
Authors 10
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Muzammil Rafique corresponding
Oslo University Hospital · University of Oslo
Affiliation as printed
Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway
Institute of Clinical Medicine, Faculty of Medicine University of Oslo Oslo Norway
Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
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Affiliation as printed
Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway
Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
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Oslo University Hospital · University of Oslo
Affiliation as printed
Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway
Institute of Clinical Medicine, Faculty of Medicine University of Oslo Oslo Norway
KG Jebsen Center for Cardiac Research University of Oslo, Norway and Center for Heart Failure Research Oslo University Hospital Oslo Norway
Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
KG Jebsen Center for Cardiac Research, University of Oslo, Norway and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway
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Affiliation as printed
Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway
Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
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Affiliation as printed
Department of Cardiology Aarhus University Hospital Aarhus Denmark
Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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Affiliation as printed
Department of Cardiology Aarhus University Hospital Aarhus Denmark
Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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Jouke Dijkstra Aachen Division of Image Processing (LKEB) Leiden University Medical Center Leiden the Netherlands Division of Image Processing (LKEB)
Leiden University Medical Center
Affiliation as printed
Division of Image Processing Leiden University Medical Center Leiden The Netherlands
Division of Image Processing, Leiden University Medical Center, Leiden, The Netherlands
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Oslo University Hospital · University of Oslo
Affiliation as printed
Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway
Institute of Clinical Medicine, Faculty of Medicine University of Oslo Oslo Norway
Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
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Oslo University Hospital · University of Oslo
Affiliation as printed
Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway
Institute of Clinical Medicine, Faculty of Medicine University of Oslo Oslo Norway
Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
-
Affiliation as printed
Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway
Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
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