Left Atrial Appendage Morphology and Function Show an Association with Stroke and Transient Ischemic Attack in Patients with Atrial Fibrillation

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Abstract

Abstract BackgroundWe aimed to correlate left atrial appendage (LAA) structure and function with the history of stroke/transient ischemic attack (TIA) in patients with atrial fibrillation (AF).MethodsWe analyzed data of 649 patients with AF who were scheduled for catheter ablation. Patients underwent cardiac CT and transesophageal echocardiography prior to ablation. LAA morphologies depicted by cardiac CT were categorized into four groups: cauliflower, chicken wing, swan and windsock shapes. ResultsMean age was 61.3±10.5 years, 33.9% were female. Prevalence of stroke/TIA was 7.1%. After adjustment for the main risk factors, LAA flow velocity ≤35.3 cm/sec (OR=2.18; 95%CI=1.09-4.61; p=0.033) and swan LAA shape (OR=2.69; 95%CI=0.96-6.86; p=0.047) independently associated with higher, while windsock LAA morphology with lower risk of stroke/TIA (OR=0.32; 95%CI=0.12-0.77; p=0.017) as compared to cauliflower LAA shape. When comparing the differences between LAA morphology groups, we measured significantly smaller LAA orifice area (389.3±137.7 mm2 in windsock vs 428.3±158.9 ml in cauliflower, p=0.021) and LAA volume (7.4±3.0 mm2 in windsock vs 8.5±4.8 mm2 in cauliflower, p=0.012) in patients with windsock LAA morphology, while LAA flow velocity did not differ significantly. ConclusionReduced LAA function and swan LAA morphology were independently associated with higher, while windsock LAA shape with lower prevalence of stroke/TIA. When comparing the differences between the various LAA morphology types, significantly lower LAA volume and LAA orifice area were measured in windsock LAA shape as compared to cauliflower LAA shape.

Authors 14

1. Judit Simon

   Semmelweis University

   Affiliation as printed

   Semmelweis University: Semmelweis Egyetem

2. Jeff M. Smit Aachen

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Leiden University Medical Center: Leids Universitair Medisch Centrum

3. Mohamed El Mahdiui Aachen

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Leiden University Medical Center: Leids Universitair Medisch Centrum

4. Lili Száraz

   Semmelweis University

   Affiliation as printed

   Semmelweis University: Semmelweis Egyetem

5. Alexander R. van Rosendael Aachen

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Leiden University Medical Center: Leids Universitair Medisch Centrum

6. Emese Zsarnóczay

   Semmelweis University

   Affiliation as printed

   Semmelweis University: Semmelweis Egyetem

7. Anikó Ilona Nagy

   Semmelweis University

   Affiliation as printed

   Semmelweis University: Semmelweis Egyetem

8. Márton Kolossváry

   Semmelweis University

   Affiliation as printed

   Semmelweis University: Semmelweis Egyetem

9. Bálint Szilveszter

   Semmelweis University

   Affiliation as printed

   Semmelweis University: Semmelweis Egyetem

10. László Gellér

    Semmelweis University

    Affiliation as printed

    Semmelweis University: Semmelweis Egyetem

11. Rob J. van der Geest Aachen

    Leiden University · Leiden University Medical Center

    Affiliation as printed

    Leiden University Medical Center: Leids Universitair Medisch Centrum

12. Jeroen Joost Bax Aachen

    Leiden University · Leiden University Medical Center

    Affiliation as printed

    Leiden University Medical Center: Leids Universitair Medisch Centrum

13. Pál Maurovich‐Horvat

    Semmelweis University

    Affiliation as printed

    Semmelweis University: Semmelweis Egyetem

14. Béla Péter Merkely

    Semmelweis University

    Affiliation as printed

    Semmelweis University: Semmelweis Egyetem