Development of a toxicokinetic-toxicodynamic model simulating chronic copper toxicity to the Zebra mussel based on subcellular fractionation
Aquatic Toxicology, vol. 241, pp. 106015
Abstract
A toxicokinetic-toxicodynamic model based on subcellular metal partitioning is presented for simulating chronic toxicity of copper (Cu) from the estimated concentration in the fraction of potentially toxic metal (PTM). As such, the model allows for considering the significance of different pathways of metal sequestration in predicting metal toxicity. In the metabolically available pool (MAP), excess metals above the metabolic requirements and the detoxification and elimination capacity form the PTM fraction. The reversibly and irreversibly detoxified fractions were distinguished in the biologically detoxified compartment, while responses of organisms were related to Cu accumulation in the PTM fraction. The model was calibrated using the data on Cu concentrations in subcellular fractions and physiological responses measured by the glutathione S-transferase activity and the lipid peroxidation level during 24-day exposure of the Zebra mussel to Cu at concentrations of 25 and 50 µg/L and varying Na + concentrations up to 4.0 mmol/L. The model was capable of explaining dynamics in the subcellular Cu partitioning, e.g. the trade-off between elimination and detoxification as well as the dependence of net accumulation, elimination, detoxification, and metabolism on the exposure level. Increases in the net accumulation rate in the MAP contributed to increased concentrations of Cu in this fraction. Moreover, these results are indicative of ineffective detoxification at high exposure levels and spill-over effects of detoxification.
Authors 8
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T.T. Yen Le corresponding
Affiliation as printed
Department of Aquatic Ecology and Centre for Water and Environmental Research (ZWU), Faculty of Biology, University of Duisburg-Essen, D-45141 Essen, Germany. Electronic address: yen.le@uni-due.de
Department of Aquatic Ecology and Centre for Water and Environmental Research (ZWU), Faculty of Biology, University of Duisburg-Essen, D-45141 Essen, Germany
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Affiliation as printed
Department of Aquatic Ecology and Centre for Water and Environmental Research (ZWU), Faculty of Biology, University of Duisburg-Essen, D-45141 Essen, Germany
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Affiliation as printed
Department of Aquatic Ecology and Centre for Water and Environmental Research (ZWU), Faculty of Biology, University of Duisburg-Essen, D-45141 Essen, Germany
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Consejo Superior de Investigaciones Científicas · Instituto de Investigacións Mariñas
Affiliation as printed
Process Engineering Group, Spanish Council for Scientific Research, IIM-CSIC, 36208 Vigo, Spain
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Consejo Superior de Investigaciones Científicas · Instituto de Investigacións Mariñas
Affiliation as printed
Process Engineering Group, Spanish Council for Scientific Research, IIM-CSIC, 36208 Vigo, Spain
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Leiden University · National Institute for Public Health and the Environment
Affiliation as printed
Center for Safety of Substances and Products, National Institute for Public Health and the Environment, Bilthoven, 3720 BA, the Netherlands; Institute for Environmental Sciences, Leiden university, 2311 EZ Leiden, the Netherlands
Center for Safety of Substances and Products, National Institute for Public Health and the Environment, Bilthoven, 3720 BA, the Netherlands
Institute for Environmental Sciences, Leiden university, 2311 EZ Leiden, the Netherlands
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Affiliation as printed
Department of Environmental Science, Faculty of Science, Radboud University Nijmegen, 6525 HP Nijmegen, the Netherlands
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Affiliation as printed
Department of Aquatic Ecology and Centre for Water and Environmental Research (ZWU), Faculty of Biology, University of Duisburg-Essen, D-45141 Essen, Germany
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