Eye-specific quantitative dynamic contrast-enhanced MRI analysis for patients with intraocular masses
Magnetic Resonance Materials in Physics Biology and Medicine, vol. 35, pp. 311–323
Abstract
Abstract Objective Dynamic contrast enhanced (DCE)-MRI is currently not generally used for intraocular masses as lesions are small, have an inhomogeneous T1 and the eye is prone to motion. The aim of this paper is to address these eye-specific challenges, enabling accurate ocular DCE-MRI. Materials & methods DCE-MRI of 19 uveal melanoma (UM) patients was acquired using a fat-suppressed 3D spoiled gradient echo sequence with TWIST (time-resolved angiography with stochastic trajectories sequence). The analysis consisted of a two-step registration method to correct for both head and eye motion. A T1 map was calculated to convert signal intensities to concentrations. Subsequently, the Tofts model was fitted voxel wise to obtain Ktrans and ve. Results Registration significantly improved the concentration curve quality (p < 0.001). The T1 of melanotic lesions was significantly lower than amelanotic lesions (888 ms vs 1350 ms, p = 0.03). The average achieved B1+ in the lesions was 91%. The average Ktrans was 0.46 min−1 (range 0.13–1.0) and the average ve was 0.22 (range 0.10–0.51). Conclusion Using this eye-specific analysis, DCE of intraocular masses is possible which might aid in the diagnosis, prognosis and follow-up of UM.
Authors 6
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Myriam G. Jaarsma‐Coes corresponding Aachen Department of Ophthalmology, Leiden University Medical Centre (LUMC) Department of Radiology, Leiden University Medical Center
Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Ophthalmology, Leiden University Medical Centre, P.O. 9600, 2300 RC, Leiden, The Netherlands. m.g.jaarsma@lumc.nl
Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands. m.g.jaarsma@lumc.nl
Department of Ophthalmology, Leiden University Medical Centre, P.O. 9600, 2300 RC, Leiden, The Netherlands
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Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands
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The Netherlands Cancer Institute
Affiliation as printed
Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Leiden University · Leiden University Medical Center · The Netherlands Cancer Institute
Affiliation as printed
Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Department of Radiotherapy, Leiden University Medical Centre, Leiden, The Netherlands
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Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Ophthalmology, Leiden University Medical Centre, P.O. 9600, 2300 RC, Leiden, The Netherlands
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Jan‐Willem M. Beenakker Aachen Department of Ophthalmology, Leiden University Medical Centre (LUMC) Department of Radiology, Leiden University Medical Center
Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Ophthalmology, Leiden University Medical Centre, P.O. 9600, 2300 RC, Leiden, The Netherlands
Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands
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