Continuous enzymatic stirred tank reactor cascade with unconventional medium yielding high concentrations of ( S )-2-hydroxyphenyl propanone and its derivatives

Catalysis Science & Technology, vol. 11, pp. 7886–7897

Abstract

How can high product concentrations be continuously provided, while dealing with substrate toxicity? Which method leads to a straight forward product isolation? The example of a model based process intensification shows how.

Authors 4

1. Reinhard Oeggl Aachen Aachen Biology and Biotechnology

   Forschungszentrum Jülich · RWTH Aachen University

   Affiliation as printed

   Aachen Biology and Biotechnology (ABBt), RWTH Aachen University, 52074 Aachen, Germany

   IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany

2. Juliane Glaser

   Forschungszentrum Jülich · Amgen (Germany)

   Affiliation as printed

   Digital Integration & Predictive Technologies (DIPT), Amgen Research (Munich) GmbH, Staffelseestr. 2, 81477 Munich, Germany

   IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany

3. Eric von Lieres

   Forschungszentrum Jülich

   Affiliation as printed

   IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany

4. Dörte Rother corresponding Aachen Aachen Biology and Biotechnology

   Forschungszentrum Jülich · RWTH Aachen University

   Affiliation as printed

   Aachen Biology and Biotechnology (ABBt), RWTH Aachen University, 52074 Aachen, Germany

   IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany