Repeatability and reproducibility of deep-learning-based liver volume and Couinaud segment volume measurement tool
Abdominal Radiology, vol. 47, pp. 143–151
Abstract
PURPOSE: Volumetric and health assessment of the liver is crucial to avoid poor post-operative outcomes following liver resection surgery. No current methods allow for concurrent and accurate measurement of both Couinaud segmental volumes for future liver remnant estimation and liver health using non-invasive imaging. In this study, we demonstrate the accuracy and precision of segmental volume measurements using new medical software, Hepatica™. METHODS: MRI scans from 48 volunteers from three previous studies were used in this analysis. Measurements obtained from Hepatica™ were compared with OsiriX. Time required per case with each software was also compared. The performance of technicians and experienced radiologists as well as the repeatability and reproducibility were compared using Bland-Altman plots and limits of agreement. RESULTS: High levels of agreement and lower inter-operator variability for liver volume measurements were shown between Hepatica™ and existing methods for liver volumetry (mean Dice score 0.947 ± 0.010). A high consistency between technicians and experienced radiologists using the device for volumetry was shown (± 3.5% of total liver volume) as well as low inter-observer and intra-observer variability. Tight limits of agreement were shown between repeated Couinaud segment volume (+ 3.4% of whole liver), segmental liver fibroinflammation and segmental liver fat measurements in the same participant on the same scanner and between different scanners. An underestimation of whole-liver volume was observed between three non-reference scanners. CONCLUSION: Hepatica™ produces accurate and precise whole-liver and Couinaud segment volume and liver tissue characteristic measurements. Measurements are consistent between trained technicians and experienced radiologists.
Authors 13
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Harvard University · Massachusetts General Hospital
Affiliation as printed
Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
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John J. Connell corresponding
Perspectum Ltd. (United Kingdom)
Affiliation as printed
Perspectum Ltd., Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK. john.connell@perspectum.com
Perspectum Ltd., Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK
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Perspectum Ltd. (United Kingdom)
Affiliation as printed
Perspectum Ltd., Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK
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Perspectum Ltd. (United Kingdom)
Affiliation as printed
Perspectum Ltd., Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK
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Perspectum Ltd. (United Kingdom)
Affiliation as printed
Perspectum Ltd., Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK
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Perspectum Ltd. (United Kingdom)
Affiliation as printed
Perspectum Ltd., Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK
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Perspectum Ltd. (United Kingdom)
Affiliation as printed
Perspectum Ltd., Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK
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Perspectum Ltd. (United Kingdom)
Affiliation as printed
Perspectum Ltd., Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK
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Perspectum Ltd. (United Kingdom)
Affiliation as printed
Perspectum Ltd., Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK
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Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands
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Affiliation as printed
Universidade de Coimbra, Coimbra, Portugal
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Perspectum Ltd. (United Kingdom)
Affiliation as printed
Perspectum Ltd., Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK
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Perspectum Ltd. (United Kingdom)
Affiliation as printed
Perspectum Ltd., Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK
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