Core outcome measurement instrument selection for physical function in hand osteoarthritis using the OMERACT Filter 2.1 process
Seminars in Arthritis and Rheumatism, vol. 51, pp. 1311–1319
Abstract
OBJECTIVE: Physical function is one of the Outcome Measures in Rheumatology (OMERACT) core outcome domains for hand osteoarthritis studies. Our aim was to select appropriate instrument(s) to measure this domain, as part of the development of a core outcome measurement set. METHODS: Following the OMERACT Filter 2.1 instrument selection process, the (function subscale of) the Australian/Canadian Hand Osteoarthritis Index (AUSCAN), Functional Index for Hand Osteoarthritis (FIHOA) and Michigan Hand Outcomes Questionnaire (MHQ) were assessed for domain match, feasibility, truth and discrimination. Data gathered from available literature, working group and patient surveys, and additional analyses in two hand osteoarthritis cohorts were used to inform a consensus process. Results were summarized in Summary of Measurements Properties tables and reviewed by the OMERACT technical advisory group. RESULTS: MHQ passed the assessment of domain match and feasibility by the working group and patient research partners. For AUSCAN important limitations in feasibility were noted, but domain match was good. FIHOA did not pass the assessment and was not taken through the follow-up assessment. Based on published literature, reliability and construct/longitudinal validity of both MHQ and AUSCAN fulfilled OMERACT standards. While clinical trial discrimination and thresholds of meaning were good for AUSCAN, results for MHQ were ambiguous. CONCLUSION: MHQ was provisionally endorsed as OMERACT core outcome measure for the core domain physical function. While AUSCAN may have better metric properties than MHQ, it received provisional endorsement as a second measure of function due to important feasibility issues. A research agenda to merit full endorsement was set.
Authors 16
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Féline P B Kroon corresponding Aachen Department of Rheumatology Department of Rheumatology, Zuyderland Medical Center
Leiden University Medical Center · Zuyderland Medisch Centrum
Affiliation as printed
Department of Rheumatology, and Department of Rheumatology, Zuyderland Medical Center, Leiden University Medical Center, Leiden, Heerlen, the Netherlands. Electronic address: fpbkroon@gmail.com
Department of Rheumatology, and Department of Rheumatology, Zuyderland Medical Center, Leiden University Medical Center, Leiden, Heerlen, the Netherlands
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Leiden University Medical Center
Affiliation as printed
Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands
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University of Ottawa · Ottawa Hospital Research Institute
Affiliation as printed
University of Ottawa, and Centre for Practice-Changing Research, Ottawa Hospital Research Institute, Ottawa, Canada
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St. Michael's Hospital · University of Toronto · Institute for Work & Health
Affiliation as printed
Musculoskeletal Health and Outcomes Research, and Department of Occupational Science and Occupational Therapy, St. Michael's Hospital and Institute for Work and Health, Rehabilitation Sciences Institute, and the Institute for Health Policy Management and Evaluation, University of Toronto, Toronto, Canada
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University of Nottingham · National Institute for Health and Care Research · Nottingham Biomedical Research Centre
Affiliation as printed
Academic Rheumatology, University of Nottingham, and National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, United Kingdom
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Inserm · Sorbonne Université · Assistance Publique – Hôpitaux de Paris · Hôpital Saint-Antoine
Affiliation as printed
Department of Rheumatology, Sorbonne Université, INSERM, Saint-Antoine hospital AP-HP, Paris, France
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Universidade da Coruña · Complexo Hospitalario Universitario A Coruña · Instituto de Investigación Biomédica de A Coruña
Affiliation as printed
Grupo de investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España
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University of Leeds · National Institute for Health and Care Research
Affiliation as printed
Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research, Leeds Biomedical Research Centre, Leeds, United Kingdom
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Affiliation as printed
Impact Accelerator Unit, School of Medicine, Keele University, Keele, United Kingdom
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Queen Elizabeth Hospital · The University of Adelaide
Affiliation as printed
Discipline of Medicine, Adelaide, and Rheumatology Department, Queen Elizabeth Hospital, University of Adelaide, Woodville South, South Australia
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Affiliation as printed
Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway
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Affiliation as printed
Department of Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
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Ludwig Boltzmann Institute for Arthritis and Rehabilitation · Medical University of Vienna
Affiliation as printed
Institute of Outcomes Research, Centre for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, and Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria
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Ludwig Boltzmann Institute for Arthritis and Rehabilitation · Medical University of Vienna
Affiliation as printed
Institute of Outcomes Research, Centre for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, and Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria
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Ghent University Hospital · Ghent University
Affiliation as printed
Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
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Leiden University Medical Center
Affiliation as printed
Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
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