Reproducibility of CT-Based Hepatocellular Carcinoma Radiomic Features across Different Contrast Imaging Phases: A Proof of Concept on SORAMIC Trial Data
Cancers, vol. 13, pp. 4638
Abstract
Handcrafted radiomic features (HRFs) are quantitative imaging features extracted from regions of interest on medical images which can be correlated with clinical outcomes and biologic characteristics. While HRFs have been used to train predictive and prognostic models, their reproducibility has been reported to be affected by variations in scan acquisition and reconstruction parameters, even within the same imaging vendor. In this work, we evaluated the reproducibility of HRFs across the arterial and portal venous phases of contrast-enhanced computed tomography images depicting hepatocellular carcinomas, as well as the potential of ComBat harmonization to correct for this difference. ComBat harmonization is a method based on Bayesian estimates that was developed for gene expression arrays, and has been investigated as a potential method for harmonizing HRFs. Our results show that the majority of HRFs are not reproducible between the arterial and portal venous imaging phases, yet a number of HRFs could be used interchangeably between those phases. Furthermore, ComBat harmonization increased the number of reproducible HRFs across both phases by 1%. Our results guide the pooling of arterial and venous phases from different patients in an effort to increase cohort size, as well as joint analysis of the phases.
Authors 14
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Abdalla Ibrahim corresponding Aachen Department of Nuclear Medicine and Comprehensive diagnostic center Aachen (CDCA)
RWTH Aachen University · Universitätsklinikum Aachen · Maastricht University · University of Liège · Maastricht University Medical Centre · Centre Hospitalier Universitaire de Liège
Affiliation as printed
Department of Nuclear Medicine and Comprehensive Diagnostic Center Aachen (CDCA), University Hospital RWTH Aachen University, 52074 Aachen, Germany
Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, 6200 MD Maastricht, The Netherlands
Division of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, University Hospital of Liege and GIGA CRC-In Vivo Imaging, University of Liege, 4000 Liege, Belgium
The D-Lab, Department of Precision Medicine, GROW—School for Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands
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Affiliation as printed
The D-Lab, Department of Precision Medicine, GROW—School for Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands
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Turkey Refaee corresponding
Maastricht University · Jazan University
Affiliation as printed
Department of Diagnostic Radiology, Faculty of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia
The D-Lab, Department of Precision Medicine, GROW—School for Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands
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Sergey P. Primakov Aachen Department of Nuclear Medicine and Comprehensive diagnostic center Aachen (CDCA)
RWTH Aachen University · Universitätsklinikum Aachen · Maastricht University
Affiliation as printed
Department of Nuclear Medicine and Comprehensive Diagnostic Center Aachen (CDCA), University Hospital RWTH Aachen University, 52074 Aachen, Germany
The D-Lab, Department of Precision Medicine, GROW—School for Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands
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Maastricht University Medical Centre
Affiliation as printed
Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, 6200 MD Maastricht, The Netherlands
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Ludwig-Maximilians-Universität München · LMU Klinikum
Affiliation as printed
Department of Radiology, University Hospital, LMU Munich, 80336 Munich, Germany
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Ludwig-Maximilians-Universität München · LMU Klinikum
Affiliation as printed
Department of Radiology, University Hospital, LMU Munich, 80336 Munich, Germany
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Ludwig-Maximilians-Universität München · LMU Klinikum
Affiliation as printed
Department of Radiology, University Hospital, LMU Munich, 80336 Munich, Germany
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Ludwig-Maximilians-Universität München · LMU Klinikum
Affiliation as printed
Department of Radiology, University Hospital, LMU Munich, 80336 Munich, Germany
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University of Liège · Centre Hospitalier Universitaire de Liège
Affiliation as printed
Division of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, University Hospital of Liege and GIGA CRC-In Vivo Imaging, University of Liege, 4000 Liege, Belgium
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Felix Manuel Mottaghy Aachen Department of Nuclear Medicine and Comprehensive diagnostic center Aachen (CDCA)
RWTH Aachen University · Universitätsklinikum Aachen · Maastricht University Medical Centre
Affiliation as printed
Department of Nuclear Medicine and Comprehensive Diagnostic Center Aachen (CDCA), University Hospital RWTH Aachen University, 52074 Aachen, Germany
Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, 6200 MD Maastricht, The Netherlands
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Maastricht University · Maastricht University Medical Centre
Affiliation as printed
Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, 6200 MD Maastricht, The Netherlands
The D-Lab, Department of Precision Medicine, GROW—School for Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands
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Ludwig-Maximilians-Universität München · LMU Klinikum
Affiliation as printed
Department of Radiology, University Hospital, LMU Munich, 80336 Munich, Germany
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Maastricht University · Maastricht University Medical Centre
Affiliation as printed
Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, 6200 MD Maastricht, The Netherlands
The D-Lab, Department of Precision Medicine, GROW—School for Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands
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