[Proton pump inhibitor-induced nephrotoxicity].

PubMed, vol. 165

Abstract

Proton pump inhibitors are widely used, and generally considered safe. In this clinical lesson two cases are presented with a strong suspicion of proton pump inhibitor induced decline of kidney function. This adverse event has only recently been identified in epidemiological studies. Our cases illustrate that chronic proton pump inhibitor nephrotoxicity can manifest subtle and may therefore be difficult to recognize. We discuss the current epidemiological evidence to support these observations, and the pathophysiology and clinical manifestations of proton pump inhibitor nephrotoxicity. In case a subject using a proton pump inhibitor shows kidney function decline, without a clear cause, withdrawal of this medication is advised. Although for an individual patient the risk may not be high, the large number of proton pump users makes that this adverse event is important on a population level.

Authors 4

1. Derk C.F. Klatte Aachen

   Leiden University Medical Center

   Affiliation as printed

   LUMC, afd. Maag-, Darm- en Leverziekten,Leiden

   Contact: D.C.F. Klatte (d.c.f.klatte@lumc.nl)

   LUMC, afd. Maag-, Darm- en Leverziekten, Leiden

2. J S Wiegersma

   University Medical Center Groningen

   Affiliation as printed

   UMCG, afd. Nefrologie, Groningen

3. Friedo Wilhelm Dekker Aachen

   Leiden University Medical Center

   Affiliation as printed

   LUMC, afd. Klinische Epidemiologie, Leiden

4. Ron T. Gansevoort

   University Medical Center Groningen

   Affiliation as printed

   UMCG, afd. Nefrologie, Groningen