Tissue factor cytoplasmic domain exacerbates post-infarct left ventricular remodeling via orchestrating cardiac inflammation and angiogenesis
Theranostics, vol. 11, pp. 9243–9261
Abstract
Our findings demonstrate that the TF cytoplasmic domain exacerbates post-infarct cardiac injury and adverse LV remodeling via differential regulation of inflammation and angiogenesis. Targeted inhibition of the TF cytoplasmic domain-mediated intracellular signaling may ameliorate post-infarct LV remodeling without perturbing coagulation.
Authors 17
-
National University of Singapore · National University Heart Centre Singapore
Affiliation as printed
Cardiovascular Research Institute (CVRI), Cardiovascular Disease TRP, National University Heart Centre Singapore (NUHCS), Singapore, Singapore
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Natl Univ Heart Ctr Singapore NUHCS, Cardiovasc Dis TRP, Cardiovasc Res Inst CVRI
-
National University of Singapore · National University Heart Centre Singapore
Affiliation as printed
Cardiovascular Research Institute (CVRI), Cardiovascular Disease TRP, National University Heart Centre Singapore (NUHCS), Singapore, Singapore
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Natl Univ Heart Ctr Singapore NUHCS, Cardiovasc Dis TRP, Cardiovasc Res Inst CVRI
-
National University of Singapore · National University Heart Centre Singapore
Affiliation as printed
Cardiovascular Research Institute (CVRI), Cardiovascular Disease TRP, National University Heart Centre Singapore (NUHCS), Singapore, Singapore
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Natl Univ Heart Ctr Singapore NUHCS, Cardiovasc Dis TRP, Cardiovasc Res Inst CVRI
-
National University Heart Centre Singapore
Affiliation as printed
Cardiovascular Research Institute (CVRI), Cardiovascular Disease TRP, National University Heart Centre Singapore (NUHCS), Singapore, Singapore
Natl Univ Heart Ctr Singapore NUHCS, Cardiovasc Dis TRP, Cardiovasc Res Inst CVRI
-
National University of Singapore · National University Heart Centre Singapore
Affiliation as printed
Cardiovascular Research Institute (CVRI), Cardiovascular Disease TRP, National University Heart Centre Singapore (NUHCS), Singapore, Singapore
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Natl Univ Heart Ctr Singapore NUHCS, Cardiovasc Dis TRP, Cardiovasc Res Inst CVRI
-
National University of Singapore · National University Heart Centre Singapore
Affiliation as printed
Cardiovascular Research Institute (CVRI), Cardiovascular Disease TRP, National University Heart Centre Singapore (NUHCS), Singapore, Singapore
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Natl Univ Singapore, National University of Singapore, Yong Loo Lin Sch Med, Dept Biochem
-
National University of Singapore · National University Heart Centre Singapore
Affiliation as printed
Cardiovascular Research Institute (CVRI), Cardiovascular Disease TRP, National University Heart Centre Singapore (NUHCS), Singapore, Singapore
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Natl Univ Singapore, National University of Singapore, Yong Loo Lin Sch Med, Dept Biochem
-
National Heart Centre Singapore
Affiliation as printed
National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore
Natl Heart Ctr Singapore, National Heart Centre Singapore, Natl Heart Res Inst
-
National University of Singapore
Affiliation as printed
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Natl Univ Singapore, National University of Singapore, Yong Loo Lin Sch Med, Dept Surg
-
National University of Singapore · Life Sciences Institute
Affiliation as printed
Immunology Program, Life Sciences Institute, National University of Singapore, Singapore
Immunology translational research program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Natl Univ Singapore, National University of Singapore, Life Sci Inst, Immunol Program
-
Henri H. Versteeg Aachen Einthoven Laboratory for Experimental Vascular Medicine Leiden Univ. (Netherlands) Einthoven Lab Expt Vasc Med
Leiden University · Leiden University Medical Center
Affiliation as printed
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, The Netherlands
Leiden Univ, Leiden University, Leiden University Medical Center (LUMC), Leiden University - Excl LUMC, Med Ctr, Einthoven Lab Expt Vasc Med
-
VIB-KU Leuven Center for Cancer Biology · KU Leuven
Affiliation as printed
Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Leuven, Belgium
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium
Katholieke Univ Leuven, KU Leuven, Leuven Canc Inst LKI
-
VIB-KU Leuven Center for Cancer Biology · KU Leuven
Affiliation as printed
Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Leuven, Belgium
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium
Katholieke Univ Leuven, KU Leuven, Leuven Canc Inst LKI
-
University Medical Center Groningen · National University of Singapore · National University Heart Centre Singapore · Duke-NUS Medical School · National Heart Centre Singapore
Affiliation as printed
Department of Cardiology, University Medical Center, Groningen, The Netherlands
National Heart Centre Singapore (NHCS), Duke-NUS Graduate Medical School, Singapore, Singapore
Duke NUS Grad Med Sch, National Heart Centre Singapore, National University of Singapore, Natl Heart Ctr Singapore NHCS
-
National University of Singapore · National University Heart Centre Singapore
Affiliation as printed
Cardiovascular Research Institute (CVRI), Cardiovascular Disease TRP, National University Heart Centre Singapore (NUHCS), Singapore, Singapore
Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore
Natl Univ Singapore, National University of Singapore, Yong Loo Lin Sch Med, Dept Psychol Med
-
Utrecht University · University Medical Center Utrecht · Netherlands Heart Institute
Affiliation as printed
Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
Netherlands Heart Institute, Utrecht, the Netherlands
Univ Utrecht, Utrecht University, Utrecht University Medical Center, Univ Med Ctr Utrecht, Div Surg Specialties, Dept Vasc Surg
-
National University of Singapore · National University Heart Centre Singapore
Affiliation as printed
Cardiovascular Research Institute (CVRI), Cardiovascular Disease TRP, National University Heart Centre Singapore (NUHCS), Singapore, Singapore
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Nanomedicine translational research programme, Centre for NanoMedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Natl Univ Singapore, National University of Singapore, Yong Loo Lin Sch Med, Ctr NanoMed, Nanomed Translat Res Programme
Cited by 26 stored of 26
No patents citing this paper on Lens.org (checked 2026-10-11).