Increased end-expiratory pressures improve lung function in near-term newborn rabbits with elevated airway liquid volume at birth

Journal of Applied Physiology, vol. 131, pp. 997–1008

Abstract

Term babies born by cesarean section have elevated airway liquid volumes, which predisposes them to respiratory distress. Treatments targeting molecular mechanisms to clear lung liquid are ineffective for term newborn respiratory distress. We showed that respiratory support with an end-expiratory pressure supports lung function in near-term rabbits with elevated airway liquid volumes at birth. This study provides further physiological understanding of lung function in newborns with elevated airway liquid volumes at risk of respiratory distress.

Authors 13

1. Erin V. McGillick corresponding

   Hudson Institute of Medical Research · Monash University

   Affiliation as printed

   The Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia

   The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia

2. Arjan B. te Pas Aachen Division of Neonatology Department of Pediatrics, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands

3. Michelle K. Croughan

   Monash University

   Affiliation as printed

   School of Physics and Astronomy, Monash University, Melbourne, Victoria, Australia

4. Kelly J. Crossley

   Hudson Institute of Medical Research · Monash University

   Affiliation as printed

   The Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia

   The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia

5. Megan J. Wallace

   Hudson Institute of Medical Research · Monash University

   Affiliation as printed

   The Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia

   The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia

6. Katie L. Lee

   Monash University

   Affiliation as printed

   School of Physics and Astronomy, Monash University, Melbourne, Victoria, Australia

7. Marta Thió

   Royal Women's Hospital · The University of Melbourne · Murdoch Children's Research Institute

   Affiliation as printed

   Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Victoria, Australia

   Newborn Research, The Royal Women’s Hospital, Melbourne, Victoria, Australia

   The Murdoch Children’s Research Institute, Melbourne, Victoria, Australia

   Newborn Research, The Royal Women's Hospital, Melbourne, Victoria, Australia

   The Murdoch Children's Research Institute, Melbourne, Victoria, Australia

8. Philip L J DeKoninck

   Erasmus MC · Hudson Institute of Medical Research · Monash University · Erasmus University Rotterdam

   Affiliation as printed

   Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center University Medical Center Rotterdam, Rotterdam, The Netherlands

   The Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia

   The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia

9. Janneke Dekker Aachen Division of Neonatology Department of Pediatrics, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands

10. Andreas Walter Flemmer

    Ludwig-Maximilians-Universität München

    Affiliation as printed

    Division of Neonatology, University Children’s Hospital and Perinatal Centre, Ludwig-Maximilians University, Munich, Germany

    Division of Neonatology, University Children's Hospital and Perinatal Centre, Ludwig-Maximilians University, Munich, Germany

11. Sophie J. E. Cramer Aachen Division of Neonatology Department of Pediatrics, Leiden University Medical Center

    Leiden University Medical Center

    Affiliation as printed

    Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands

12. Stuart B. Hooper

    Hudson Institute of Medical Research · Monash University

    Affiliation as printed

    The Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia

    The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia

13. Marcus J. Kitchen

    Monash University

    Affiliation as printed

    School of Physics and Astronomy, Monash University, Melbourne, Victoria, Australia