Magnetic measurement methods to probe nanoparticle–matrix interactions

Physical Sciences Reviews, vol. 8, pp. 1273–1303

Abstract

Abstract Magnetic nanoparticles (MNPs) are key elements in several biomedical applications, e.g., in cancer therapy. Here, the MNPs are remotely manipulated by magnetic fields from outside the body to deliver drugs or generate heat in tumor tissue. The efficiency and success of these approaches strongly depend on the spatial distribution and quantity of MNPs inside a body and interactions of the particles with the biological matrix. These include dynamic processes of the MNPs in the organism such as binding kinetics, cellular uptake, passage through cell barriers, heat induction and flow. While magnetic measurement methods have been applied so far to resolve the location and quantity of MNPs for therapy monitoring, these methods can be advanced to additionally access these particle–matrix interactions. By this, the MNPs can further be utilized as probes for the physical properties of their molecular environment. In this review, we first investigate the impact of nanoparticle–matrix interactions on magnetic measurements in selected experiments. With these results, we then advanced the imaging modalities magnetorelaxometry imaging and magnetic microsphere tracking to spatially resolve particle–matrix interactions.

Authors 10

1. Maik Liebl corresponding

   Physikalisch-Technische Bundesanstalt

   Affiliation as printed

   Physikalisch-Technische Bundesanstalt , Abbestraße 2-12, 10587 Berlin , Germany

2. Dietmar Eberbeck

   Physikalisch-Technische Bundesanstalt

   Affiliation as printed

   Physikalisch-Technische Bundesanstalt , Abbestraße 2-12, 10587 Berlin , Germany

3. Annelies Coene

   Ghent University · Cancer Research Institute Ghent

   Affiliation as printed

   Cancer Research Institute Ghent (CRIG) , 9000 Ghent , Belgium

   Department of Electromechanical, Systems and Metal Engineering , Ghent University , 9052 Ghent , Belgium

4. Jonathan Leliaert

   Ghent University

   Affiliation as printed

   Department of Solid State Sciences , Ghent University , 9000 Ghent , Belgium

5. Philine Jauch

   Leibniz Institute of Surface Engineering · Leipzig University

   Affiliation as printed

   Division of Surface Physics, Department of Physics and Earth Sciences , University of Leipzig , Linnéstrasse 5, 04103 Leipzig , Germany

   Leibniz Institute of Surface Engineering (IOM) , Permoserstrasse 15, 04318 Leipzig , Germany

6. Margarita Kruteva

   Forschungszentrum Jülich

   Affiliation as printed

   Jülich Centre for Neutron Science (JCNS-1) and Institute for Complex Systems (ICS-1), Forschungszentrum Jülich GmbH , Leo-Brandt-Straße, 52425 Jülich , Germany

7. Lisa Fruhner Aachen Institute of Physical Chemistry

   Forschungszentrum Jülich · RWTH Aachen University

   Affiliation as printed

   Institute of Physical Chemistry , RWTH Aachen University , Landoltweg 2, 52056 Aachen , Germany

   Jülich Centre for Neutron Science (JCNS-1) and Institute for Complex Systems (ICS-1), Forschungszentrum Jülich GmbH , Leo-Brandt-Straße, 52425 Jülich , Germany

8. Lester C. Barnsley

   Forschungszentrum Jülich · Heinz Maier-Leibnitz Zentrum

   Affiliation as printed

   Forschungszentrum Jülich GmbH , Jülich Centre for Neutron Science at MLZ , Lichtenbergstr. 1, 85748 Garching , Germany

9. Stefan G. Mayr

   Leibniz Institute of Surface Engineering · Leipzig University

   Affiliation as printed

   Division of Surface Physics, Department of Physics and Earth Sciences , University of Leipzig , Linnéstrasse 5, 04103 Leipzig , Germany

   Leibniz Institute of Surface Engineering (IOM) , Permoserstrasse 15, 04318 Leipzig , Germany

10. Frank Wiekhorst

    Physikalisch-Technische Bundesanstalt

    Affiliation as printed

    Physikalisch-Technische Bundesanstalt , Abbestraße 2-12, 10587 Berlin , Germany