Repolarization characteristics indicate electrical instability in ventricular arrhythmia originating from papillary muscle

EP Europace, vol. 23

Abstract

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): DZHK (German Center for Cardiovascular Research) Introduction Cardiac arrhythmia originating from the papillary muscle can trigger ventricular fibrillation and cause sudden cardiac death even in the absence of structural heart disease. Yet, no clinical parameters are known to reflect the propensity of arrhythmia to degenerate into ventricular fibrillation. Purpose We aimed at identification of parameters associated with degeneration of ventricular arrhythmia into ventricular fibrillation. Methods Ventricular arrhythmia was induced by aconitine injection into the papillary muscle of healthy sheep (n = 12) in an open-chest model. Endocardial high-density-mapping and epicardial mapping were performed. We determined repolarization time and activation-recovery-interval according to the Wyatt method. Results During focal arrhythmia faster conduction occurred in longitudinal and basal direction than transversal and apical direction. The electrical restitution curve, modelling relation of diastolic interval and activation-recovery-interval, is steeper in aconitine-induced ventricular arrhythmia than in ventricular pacing or sinus rhythm. Steeper restitution curves reflect electrical instability and propensity to degenerate into ventricular fibrillation. The repolarization-related parameters activation-recovery interval and repolarization time exhibit higher heterogeneity per beat in ventricular arrhythmia preceding degeneration into ventricular fibrillation. Repolarization time in relation to cycle length (RT/CL), which can easily be measured during electrophysiological procedures, differentiates self-limiting from degenerating arrhythmia with high specificity and sensitivity. Conclusion In structurally normal ovine hearts, the ratio of repolarization and cycle length (RT/CL) in ventricular arrhythmia and greater dispersion of repolarization are indicators of subsequent degeneration into ventricular fibrillation. While dispersion of repolarization is not easily acquired in clinical routine, a simple index (RT/CL) may be sufficient to differentiate between self-limiting and electrically instable arrhythmia with propensity to degenerate to ventricular fibrillation. Abstract Figure. Repolarization in VA model

Authors 11

1. Paula Münkler
   Affiliation as printed

   University Heart & Vascular Center Hamburg, Hamburg, Germany

2. Niklas Klatt
   Affiliation as printed

   University Heart & Vascular Center Hamburg, Hamburg, Germany

3. Katharina Scherschel
   Affiliation as printed

   University Heart & Vascular Center Hamburg, Hamburg, Germany

4. Paweł Kuklik

   Asklepios Klinik St. Georg · Asklepios

   Affiliation as printed

   Asklepios Clinic St. Georg, Cardiology/Electrophysiology, Hamburg, Germany

5. Christiane Jungen Aachen

   Leiden University Medical Center

   Affiliation as printed

   Leiden University Medical Center, Cardiology, Leiden, Netherlands (The)

6. Erol Cavus
   Affiliation as printed

   University Heart & Vascular Center Hamburg, Hamburg, Germany

7. Christian Eickholt

   Asklepios Klinik St. Georg · Asklepios

   Affiliation as printed

   Asklepios Clinic St. Georg, Cardiology/Electrophysiology, Hamburg, Germany

8. Jan Christoph

   Universitätsmedizin Göttingen · University of Göttingen

   Affiliation as printed

   University Medical Center of Gottingen (UMG), Cardiology and Pneumology, Goettingen, Germany

9. Torsten Christ

   University Medical Center Hamburg-Eppendorf

   Affiliation as printed

   University Medical Center Hamburg Eppendorf, Pharmacology/Toxicology, Hamburg, Germany

10. Stephan Willems

    Asklepios Klinik St. Georg · Asklepios

    Affiliation as printed

    Asklepios Clinic St. Georg, Cardiology/Electrophysiology, Hamburg, Germany

11. Paulus F. Kirchhof
    Affiliation as printed

    University Heart & Vascular Center Hamburg, Hamburg, Germany