Author response: Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

Abstract

Experiments in a mouse model for Alzheimer’s disease using germ-free and conventionally housed animals reveal that microbiota-derived short-chain fatty acids promote the deposition of cerebral Aβ plaques.

Authors 22

1. Alessio Vittorio Colombo

   German Center for Neurodegenerative Diseases · German Center for Neurodegenerative Diseases (DZNE) Dresden

   Affiliation as printed

   German Center for Neurodegenerative Diseases (DZNE)

2. Rebecca Sadler

   Institut für Schlaganfall- und Demenzforschung · Ludwig-Maximilians-Universität München

   Affiliation as printed

   Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich

3. Gemma Llovera

   Institut für Schlaganfall- und Demenzforschung · Ludwig-Maximilians-Universität München

   Affiliation as printed

   Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich

4. Vikramjeet Singh

   Institut für Schlaganfall- und Demenzforschung · Ludwig-Maximilians-Universität München

   Affiliation as printed

   Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich

5. Stefan Roth

   Institut für Schlaganfall- und Demenzforschung · Ludwig-Maximilians-Universität München

   Affiliation as printed

   Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich

6. Steffanie Heindl

   Institut für Schlaganfall- und Demenzforschung · Ludwig-Maximilians-Universität München

   Affiliation as printed

   Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich

7. Laura Sebastián Monasor

   German Center for Neurodegenerative Diseases · German Center for Neurodegenerative Diseases (DZNE) Dresden

   Affiliation as printed

   German Center for Neurodegenerative Diseases (DZNE)

8. Aswin Verhoeven Aachen Center for Proteomics and Metabolomics

   Leiden University Medical Center

   Affiliation as printed

   Center for Proteomics and Metabolomics, Leiden University Medical Center (LUMC)

9. Finn Peters

   German Center for Neurodegenerative Diseases · German Center for Neurodegenerative Diseases (DZNE) Dresden

   Affiliation as printed

   German Center for Neurodegenerative Diseases (DZNE)

10. Samira Parhizkar

    Ludwig-Maximilians-Universität München

    Affiliation as printed

    Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München

11. Frits Kamp

    Ludwig-Maximilians-Universität München

    Affiliation as printed

    Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München

12. Mercedes Gomez de Agüero

    University Hospital of Bern

    Affiliation as printed

    Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital

13. Andrew J. Macpherson

    University Hospital of Bern

    Affiliation as printed

    Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital

14. Edith Winkler

    German Center for Neurodegenerative Diseases · German Center for Neurodegenerative Diseases (DZNE) Dresden · Ludwig-Maximilians-Universität München

    Affiliation as printed

    German Center for Neurodegenerative Diseases (DZNE)

    Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München

15. Jochen Wolfgang Herms

    German Center for Neurodegenerative Diseases · Munich Cluster for Systems Neurology · Institut für Neuropathologie · German Center for Neurodegenerative Diseases (DZNE) Dresden · Ludwig-Maximilians-Universität München

    Affiliation as printed

    Center for Neuropathology and Prion Research, Ludwig-Maximilians University Munich

    German Center for Neurodegenerative Diseases (DZNE)

    Munich Cluster for Systems Neurology (SyNergy)

16. Corinne Benakis

    Institut für Schlaganfall- und Demenzforschung · Ludwig-Maximilians-Universität München

    Affiliation as printed

    Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich

17. Martin Dichgans

    Munich Cluster for Systems Neurology · Institut für Schlaganfall- und Demenzforschung · Ludwig-Maximilians-Universität München

    Affiliation as printed

    Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich

    Munich Cluster for Systems Neurology (SyNergy)

18. Harald Steiner

    German Center for Neurodegenerative Diseases · German Center for Neurodegenerative Diseases (DZNE) Dresden · Ludwig-Maximilians-Universität München

    Affiliation as printed

    German Center for Neurodegenerative Diseases (DZNE)

    Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München

19. Martin A. Giera Aachen Center for Proteomics and Metabolomics

    Leiden University Medical Center

    Affiliation as printed

    Center for Proteomics and Metabolomics, Leiden University Medical Center (LUMC)

20. Christian Haass

    German Center for Neurodegenerative Diseases · Munich Cluster for Systems Neurology · German Center for Neurodegenerative Diseases (DZNE) Dresden · Ludwig-Maximilians-Universität München

    Affiliation as printed

    German Center for Neurodegenerative Diseases (DZNE)

    Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München

    Munich Cluster for Systems Neurology (SyNergy)

21. Sabina Tahirović

    German Center for Neurodegenerative Diseases · German Center for Neurodegenerative Diseases (DZNE) Dresden

    Affiliation as printed

    German Center for Neurodegenerative Diseases (DZNE)

22. Arthur Liesz

    Munich Cluster for Systems Neurology · Institut für Schlaganfall- und Demenzforschung · Ludwig-Maximilians-Universität München

    Affiliation as printed

    Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich

    Munich Cluster for Systems Neurology (SyNergy)