Stimuli‐Responsive Nanotheranostics
Advanced Healthcare Materials, vol. 10, pp. e2100243
Abstract
In recent decades, the incidence of cancer has increased significantly, which proves to be a great threaten to human life, and brings heavy burden and pain to individuals, families, and society.With the cross-fusion of traditional medical imaging and targeting technology, molecular imaging has been expected to help the non-invasive and quantitative observation of cancer cell occurrence, development and metastasis at the cellular and molecular level, which is conducive to the grasp of cancer activity in vivo, and also to diagnose cancer as early as possible.Moreover, thanks to the combined therapy of surgery, radiotherapy, chemotherapy and immunotherapy, better treatment and improved overall efficacy have been achieved up to now.As a result, more lives can be saved and quality of life can be improved.However, one big challenge remaining now is the responsive evaluation of therapy.To date, it is hard to estimate the curing effects exactly, nor the appropriate dosage that is needed to be applied.Consequently, it is difficult to adjust the treatment plan in a truly personalized manner.Theranostics, with simultaneously therapeutic and diagnostic functions, is arguably of greatest help in patient stratification and treatment selection.Meanwhile, considering the rapid development of nanomedicine in addressing biomedical challenges, nanotheranostics-that possesses the advantages of both theranostics and nanomedicine-has achieved
Authors 5
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Yanglong Hou corresponding
Affiliation as printed
BIC‐ESAT School of Materials Science and Engineering Peking University Beijing 100871 China
BIC-ESAT School of Materials Science and Engineering Peking University Beijing 100871 China
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Wenbo Bu corresponding
Affiliation as printed
Department of Materials Science Fudan University Shanghai 200433 China
Department of Materials Science Fudan University Shanghai 200433 China
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Hua Ai corresponding
Affiliation as printed
National Engineering Research Center for Biomaterials Sichuan University Chengdu 610065 China
National Engineering Research Center for Biomaterials Sichuan University Chengdu 610065 China
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Zheng‐Rong Lu corresponding
Case Western Reserve University
Affiliation as printed
Department of Biomedical Engineering Case Western Reserve University Cleveland OH 44106 USA
Department of Biomedical Engineering Case Western Reserve University Cleveland OH 44106 USA
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Institute for Experimental Molecular Imaging (ExMI) RWTH Aachen University Clinic and Helmholtz Institute for Biomedical Engineering Pauwelsstrasse 30 Aachen 52074 Germany
Institute for Experimental Molecular Imaging (ExMI) RWTH Aachen University Clinic and Helmholtz Institute for Biomedical Engineering Pauwelsstrasse 30 Aachen 52074 Germany
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