Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project
Microorganisms, vol. 9, pp. 696
Abstract
serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project gathered ST1 IPD surveillance data from sites globally and aimed to estimate PCV10/13 impact on ST1 IPD incidence. We estimated ST1 IPD incidence rate ratios (IRRs) comparing the pre-PCV10/13 period to each post-PCV10/13 year by site using a Bayesian multi-level, mixed-effects Poisson regression and all-site IRRs using a linear mixed-effects regression (N = 45 sites). Following PCV10/13 introduction, the incidence rate (IR) of ST1 IPD declined among all ages. After six years of PCV10/13 use, the all-site IRR was 0.05 (95% credibility interval 0.04-0.06) for all ages, 0.05 (0.04-0.05) for <5 years of age, 0.08 (0.06-0.09) for 5-17 years, 0.06 (0.05-0.08) for 18-49 years, 0.06 (0.05-0.07) for 50-64 years, and 0.05 (0.04-0.06) for ≥65 years. PCV10/13 use in infant immunization programs was followed by a 95% reduction in ST1 IPD in all ages after approximately 6 years. Limited data availability from the highest ST1 disease burden countries using a 3+0 schedule constrains generalizability and data from these settings are needed.
Authors 61
-
Julia Catherine Bennett corresponding
Affiliation as printed
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
-
Affiliation as printed
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
-
Affiliation as printed
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
-
Affiliation as printed
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
-
Maria Deloria Knoll corresponding
Affiliation as printed
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
-
Affiliation as printed
Independent Consultant, 1296 Coppet, Switzerland
-
Affiliation as printed
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
-
Kenya Medical Research Institute · KEMRI-Wellcome Trust Research Programme
Affiliation as printed
KEMRI-Wellcome Trust Research Programme, Epidemiology and Demography Department, Centre for Geographic Medicine-Coast, P.O. Box 230-80108 Kilifi, Kenya
-
Affiliation as printed
World Health Organization, 1202 Geneva, Switzerland
-
Affiliation as printed
Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
-
Affiliation as printed
National Laboratory for Meningitis and Pneumococcal Infections, Center of Bacteriology, Institute Adolfo Lutz (IAL), São Paulo 01246-902, Brazil
-
Centers for Disease Control and Prevention · National Center for Emerging and Zoonotic Infectious Diseases
Affiliation as printed
Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK 99508, USA
-
Affiliation as printed
Department of Infectious Diseases, Italian National Institute of Health (Istituto Superiore di Sanità, ISS), 00161 Rome, Italy
-
Instituto de Salud Pública de Navarra · Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Affiliation as printed
CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
Instituto de Salud Pública de Navarra—IdiSNA, 31003 Pamplona, Navarra, Spain
-
Affiliation as printed
Singapore Ministry of Health, Communicable Diseases Division, Singapore 308442, Singapore
-
Affiliation as printed
Centre for Disease Control, Department of Health and Community Services, Darwin, NT 8000, Australia
-
University of Liverpool · Malawi-Liverpool-Wellcome Trust Clinical Research Programme
Affiliation as printed
Institute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool CH64 7TE, UK
Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Chichiri, P.O. Box 30096 Blantyre, Malawi
-
Ben-Gurion University of the Negev
Affiliation as printed
Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501 Beer-Sheva, Israel
-
Affiliation as printed
Bacteria, Parasites and Fungi, Statens Serum Institut, DK-2300 Copenhagen, Denmark
-
Affiliation as printed
Santé Publique France, the French National Public Health Agency, Saint Maurice CEDEX, 94415 Paris, France
-
Affiliation as printed
Epidemiology Department, Dirección General de Salud Pública, 28009 Madrid, Spain
-
Affiliation as printed
Department of Social and Preventive Medicine, Laval University, Québec, QC G1V 0A6, Canada
-
Universitair Ziekenhuis Leuven · KU Leuven
Affiliation as printed
Department of Microbiology, Immunology and Transplantation, KU Leuven, BE-3000 Leuven, Belgium
National Reference Centre for Streptococcus Pneumoniae, University Hospitals Leuven, 3000 Leuven, Belgium
-
National Public Health Organization
Affiliation as printed
National Public Health Organisation, 15123 Athens, Greece
-
New Zealand Institute for Public Health and Forensic Science
Affiliation as printed
Epidemiology Team, Institute of Environmental Science and Research, Porirua, Wellington 5240, New Zealand
-
National Institute of Public Health
Affiliation as printed
Communicable Diseases Centre, National Institute of Public Health, 1000 Ljubljana, Slovenia
-
Johns Hopkins University · Kenya Medical Research Institute · KEMRI-Wellcome Trust Research Programme
Affiliation as printed
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
KEMRI-Wellcome Trust Research Programme, Epidemiology and Demography Department, Centre for Geographic Medicine-Coast, P.O. Box 230-80108 Kilifi, Kenya
-
Affiliation as printed
Swiss National Reference Centre for Invasive Pneumococci, Institute for Infectious Diseases, University of Bern, 3012 Bern, Switzerland
-
Affiliation as printed
Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China
-
The University of Sydney · Children's Hospital at Westmead
Affiliation as printed
National Centre for Immunisation Research and Surveillance and Discipline of Child and Adolescent Health, Children’s Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia
National Centre for Immunisation Research and Surveillance and Discipline of Child and Adolescent Health, Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia
-
Alberta Health Services · University of Calgary
Affiliation as printed
Department of Pediatrics, University of Calgary, and Alberta Health Services, Calgary, AB T3B 6A8, Canada
-
National Health Laboratory Service · University of the Witwatersrand · National Institute for Communicable Diseases
Affiliation as printed
Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg 2192, South Africa
School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa
-
National Institute for Public Health and the Environment
Affiliation as printed
National Institute for Public Health and the Environment, 3721 MA Bilthoven, The Netherlands
-
National Institute of Public Health
Affiliation as printed
National Institute of Public Health (NIPH), 100 42 Praha, Czech Republic
-
National University Hospital of Iceland
Affiliation as printed
Department of Clinical Microbiology, Landspitali—The National University Hospital, Hringbraut, 101 Reykjavik, Iceland
-
Affiliation as printed
Immunisation and Countermeasures Division, Public Health England, London NW9 5EQ, UK
-
Affiliation as printed
Public Health Scotland, Glasgow G2 6QE, UK
-
London School of Hygiene & Tropical Medicine · MRC Unit the Gambia · Murdoch Children's Research Institute · Medical Research Council
Affiliation as printed
Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St, London WC1E 7HT, UK
Medical Research Council Unit the Gambia at London School of Hygiene & Tropical Medicine, P.O. Box 273 Banjul, The Gambia
New Vaccines Group, Murdoch Children’s Research Institute, Parkville, Melbourne, VIC 3052, Australia
New Vaccines Group, Murdoch Children's Research Institute, Parkville, Melbourne, VIC 3052, Australia
-
Public Health Authority of the Slovak Republic
Affiliation as printed
National Reference Centre for Pneumococcal and Haemophilus Diseases, Regional Authority of Public Health, 975 56 Banská Bystrica, Slovakia
-
Affiliation as printed
Toronto Invasive Bacterial Diseases Network, Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada
-
Health Protection Surveillance Centre
Affiliation as printed
HSE Health Protection Surveillance Centre, Mountjoy, Dublin D01 A4A3, Ireland
-
Public Health Agency of Sweden
Affiliation as printed
Department of Microbiology, Public Health Agency of Sweden, 171 82 Solna, Sweden
-
National Center for Communicable Diseases · Ministry of Health
Affiliation as printed
National Center of Communicable Diseases (NCCD), Ministry of Health, Bayanzurkh District, Ulaanbaatar 13336, Mongolia
-
Universitat Internacional de Catalunya · Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Affiliation as printed
CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
Medicine Department, Universitat Internacional de Catalunya, 08017 Barcelona, Spain
Molecular Microbiology Department, Hospital Sant Joan de Déu Research Institute, 08950 Esplugues de Llobregat, Barcelona, Spain
-
Tampere University · Finnish Institute for Health and Welfare · University of Tampere
Affiliation as printed
Department of Health Security, Finnish Institute for Health and Welfare, 00271 Helsinki, Finland
Health Sciences Unit, Faculty of Social Sciences, University of Tampere, 33100 Tampere, Finland
-
National Laboratory of Health, Environment and Food
Affiliation as printed
Centre for Medical Microbiology, National Laboratory of Health, Environment and Food, 2000 Maribor, Slovenia
-
Centers for Disease Control and Prevention · National Center for Immunization and Respiratory Diseases
Affiliation as printed
National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
-
Instituto de Salud Pública de Chile
Affiliation as printed
Instituto de Salud Pública de Chile, Santiago 7780050, Santiago Metropolitan, Chile
-
Child Health Research Foundation
Affiliation as printed
Child Health Research Foundation, Dhaka 1207, Bangladesh
-
Affiliation as printed
Ministry of Health and Medical Services, Suva, Fiji
-
Affiliation as printed
Centre for Disease Prevention and Control of Latvia, 1005 Riga, Latvia
Doctoral Studies Department, Riga Stradinš University, 1007 Riga, Latvia
-
Kenya Medical Research Institute · KEMRI-Wellcome Trust Research Programme
Affiliation as printed
KEMRI-Wellcome Trust Research Programme, Epidemiology and Demography Department, Centre for Geographic Medicine-Coast, P.O. Box 230-80108 Kilifi, Kenya
-
Affiliation as printed
National Reference Centre for Bacterial Meningitis, National Medicines Institute, 00-725 Warsaw, Poland
-
National Hospital Organization · National Mie Hospital
Affiliation as printed
Infectious Disease Center and Department of Clinical Research, National Hospital Organization Mie Hospital, Tsu, Mie 514-0125, Japan
-
Mark van der Linden Aachen National Reference Center for Streptococci Department of Medical Microbiology
Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
National Reference Center for Streptococci, Department of Medical Microbiology, University Hospital RWTH Aachen, 52074 Aachen, Germany
-
Centers for Disease Control and Prevention · National Center for Immunization and Respiratory Diseases · Centers for Disease Control and Prevention
Affiliation as printed
Centers for Disease Control and Prevention (CDC), Center for Global Health (CGH), Division of Global Health Protection (DGHP), P.O. Box 606-00621 Nairobi, Kenya
National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Centers for Disease Control and Prevention (CDC), Center for Global Health (CGH), Division of Global Health Protection (DGHP), P.O. Box 606-00621 Nairobi, Kenya
-
National Health Laboratory Service · University of the Witwatersrand · National Institute for Communicable Diseases
Affiliation as printed
Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg 2192, South Africa
School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Braamfontein, Johannesburg 2000, South Africa
-
Norwegian Institute of Public Health
Affiliation as printed
Department of Infection Control and Vaccine, Norwegian Institute of Public Health, 0456 Oslo, Norway
-
Affiliation as printed
Department of Pediatrics, Yale New Haven Children’s Hospital, New Haven, CT 06504, USA
Department of Pediatrics, Yale New Haven Children's Hospital, New Haven, CT 06504, USA
-
Centre Hospitalier Universitaire Ibn Rochd · University of Hassan II Casablanca
Affiliation as printed
Bacteriology-Virology and Hospital Hygiene Laboratory, Ibn Rochd University Hospital Centre, Casablanca 20250, Morocco
Department of Microbiology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco
-
Affiliation as printed
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Cited by 23 stored of 23
No patents citing this paper on Lens.org (checked 2026-10-06).